The mechanisms of obesity-induced breast carcinogenesis are not clear. One hypothesis is that high levels of adipokines could promote breast cancer (BC) development. The aim of this study was to investigate the correlation of resistin, visfatin, adiponectin, and leptin with BC risk in pre- and postmenopausal females. A total of 82 BC newly diagnosed and histologically confirmed patients and 68 ...

Introduction: Alterations in the synthesis of cytokines have been demonstrated in gestational diabetes (GDM), but the association of cytokines with shortand long-term glycemic markers has not been defined clearly. In this study, the variations in the plasma levels of visfatin, TNF-α, IL-1β, IL-6, and IL-10 were investigated and theirassociations with glycemic markers -HbA1C, fructosamine, 1,5-a...

Background: Visfatin is a multifaceted protein that plays an important role in diabetes (DM) and periodontitis (CP). It has been known during inflammation, the production of IL-1b, TNF-a can be induced by visfatin. Therefore, visfatin mediator for both diseases. The aim this study to investigation levels serum, saliva GCF samples non-diabetic patients controlled uncontrolled diabetic patients, ...

BACKGROUND/OBJECTIVE Visfatin, also known as nicotiamide phosphoribosyltransferase or pre-B cell colony enhancing factor, is a pro-inflammatory cytokine whose serum level is increased in sepsis and cancer as well as in obesity. Here we report a pro-inflammatory role of visfatin in the brain, to mediate sickness responses including anorexia, hyperthermia and hypoactivity. METHODOLOGY Rats were...

Visfatin is a novel adipocytokine exerting insulin-mimetic effects in various insulin-sensitive tissues such as liver, muscle, and fat. In contrast, interleukin (IL)-6 is a proinflammatory adipose-secreted factor that induces insulin resistance and plasma concentrations that correlate with the development of type 2 diabetes mellitus. In the present study, the impact of IL-6 on visfatin gene exp...

background: recent epidemiological studies demonstrate that obesity is associated with an increased risk for breast cancer in women. increased estrogen levels are suggested as one possible explanation, but this does not fully explain the relationship between obesity and breast cancer. one alternative explanation is secretion by adipocytes of metabolites, hormones and cytokines, collectively kno...

Resistin and visfatin have been proposed as playing a role in the pathogenesis of insulin resistance. We assessed the relationship between their serum concentrations and insulin resistance in lean, obese diabetic and obese non-diabetic. We explore their relationship with inflammatory markers and anthropometric parameters in obese patients. We measured serum resistin, visfatin levels in obese di...

OBJECTIVE To assess the effects of weight loss on serum adipokine levels in polycystic ovary syndrome (PCOS). METHODS We determined serum leptin, adiponectin, resistin, and visfatin levels in 60 overweight/obese women with PCOS and 48 BMI-matched female volunteers. Measurements were repeated after 24 weeks of treatment with orlistat 120 mg 3 times per day along with an energy-restricted diet....

Aims. Although altered endocrine changes following bariatric surgery in morbidly obese patients with diabetes have been demonstrated by previous studies, little is known about their effects on low BMI patients of T2DM. We investigated the changes in adipokines and sICAM-1 in Chinese subjects with low BMI and T2DM after LRYGB and explored their relationship with postsurgical insulin sensitivity....

OBJECTIVE This study is to determine if Adenovirus type 36 (Ad36) infection is related to macrophage infiltration in the obese group and non-obese group and the related molecular mechanisms. METHODS Ninety obesity patients and 95 non-obesity Uygur individuals were enrolled in this study. CD68 levels in abdominal subcutaneous and omental adipose tissues were detected by immunohistochemistry. T...