background: the aim of this preliminary study was to assess the safety and efficacy of high-dose oral vitamin d3 supplementation during pregnancy in women with multiple sclerosis (ms) in isfahan, iran. methods: in a single center open-label randomized, controlled clinical phase i/ii pilot study, 15 pregnant women with confirmed ms with low serum 25-hydroxyvitamin d (25(oh)d) levels were randoml...

PURPOSE Vitamin D inadequacy is a global health concern in athletes as well as the general population. Whilst the role of vitamin D in skeletal health is well defined, there remains uncertainty over whether vitamin D supplementation has an added benefit beyond bone health. METHODS This randomised placebo-controlled trial in healthy male and female Gaelic footballers (n = 42) investigated the ...

Vitamin D and calcium affect several pathways involved in inflammation, tumor growth, and immune surveillance relevant to carcinogenesis. Also, epidemiologic evidence indicates that calcium and vitamin D may reduce risk for developing colorectal adenomas and cancer. To investigate the effects of calcium and vitamin D on biomarkers of inflammation in colorectal adenoma patients, we conducted a p...

BACKGROUND Epidemiological data show significant associations of vitamin D deficiency and autoimmune diseases. Vitamin D may prevent autoimmunity by stimulating naturally occurring regulatory T cells. OBJECTIVES To elucidate whether vitamin D supplementation increases Tregs frequency (%Tregs) within circulating CD4+ T cells. METHODS We performed an uncontrolled vitamin D supplementation tri...

BACKGROUND Diabetes and vitamin D deficiency are global epidemics. Researchers have long been exploring the role of potentially modifiable factors to manage type 2 diabetes. We conducted a systematic review of prospective studies and randomized controlled trials that involved vitamin D supplementation and specifically intended to study glycemic outcomes related to type 2 diabetes. METHODS Two...

BACKGROUND Black men exhibit a high prevalence of vitamin D deficiency as well as a higher incidence of prostate cancer and higher mortality rates from prostate cancer than Whites. There are few data about the effect of vitamin D3 (cholecalciferol) supplementation on prostate-specific antigen (PSA) in healthy Black men. METHODS During three winters from 2007 to 2010, 105 Black men (median age...

OBJECTIVE Inconsistent findings from epidemiological studies have continued the controversy over the role of oral vitamin D supplementation in reducing blood pressure in normotensive or hypertensive populations. METHODS We performed a literature search up to December 2009, with no restrictions. Only double-blind randomized controlled trials (RCTs) of oral vitamin D supplementation in normoten...

background: vitamin d supplementation during pregnancy has been supposed to defend against adverse gestational outcomes. objective: this randomized clinical trial study was conducted to assess the effects of 50,000 iu of vitamin d every two weeks supplementation on the incidence of gestational diabetes (gdm), gestational hypertension, preeclampsia and preterm labor, vitamin d status at term and...

Vitamin D deficiency is highly prevalent among critically ill patients and may be associated with adverse outcomes. Failure of conventional vitamin D supplementation in correcting deficiency has called for studies to evaluate the efficacy and safety of a high-dose regime in critically ill patients. High-dose vitamin D supplementation that corrects a deficient state effectively and safely allows...