BACKGROUND: Neonatal Vitamin K prophylaxis is an effective intervention for reducing vitamin K deficiency bleeding. A recently published report of parental refusal of vitamin K prompted an investigation of the prevalence and characteristics of this group, and exploration of whether these same parents were likely to subsequently refuse immunization for their children. METHODS: We conducted a ret...

Vitamin K is a nutrient that was originally identified as an essential factor for blood coagulation. Recently, vitamin K has emerged as a potential protector against osteoporosis, atherosclerosis, and hepatocarcinoma. Accumulated evidence indicates that subclinical non-hemostatic vitamin K deficiency in extrahepatic tissues, particularly in bone and possibly in vasculature, exists widely in the...

Although hip fracture is considered to be associated with hypovitaminosis D and K, few reports have previously studied both of them. We have studied the vitamin D- and K-status as well as the general nutritional status in ninety-nine patients with hip fracture. Mean serum concentration of 25hydroxy-vitamin D (25OH-D) in female fractured patients was only approximately 9 ng/mL, suggesting severe...

Vitamin K is a cofactor in the -glutamyl carboxylation pathway, a posttranslational conversion of specific glutamate residues into -carboxyglutamic acid (Gla) residues, catalyzed by the endoplasmic reticulum enzyme -glutamyl carboxylase. The substrates of carboxylase are the so-called vitamin K–dependent proteins, which are involved in diverse physiological processes such as blood coagulation, ...

While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a n...

Vitamin K comprises a group of substances, which are widespread in nature and are an essential co-factor in humans in the synthesis of several proteins that play a role in haemostasis and others that may be important in calcium homeostasis. The K vitamins all contain the 2-methyl-1,4-naphthoquinone (menadione) moiety, and the various naturally occurring forms differ in the alkyl substituent at ...

Low vitamin K nutritional status has been associated with increased risk of fracture, however inconsistent results exist to support the role of vitamin K on bone mineral density depending on ethnic difference and gender. Our objective was to determine vitamin K intake in Korean adults, examine correlation between vitamin K intake and bone mineral density. This study analyzed raw data from the f...

BACKGROUND/AIM Vitamin D3 has increased risk of toxicity due to its common use in multivitamin preparations. Vitamin K and vitamin A play an important role in vitamin D action. The goal of the current study was to compare the protective effects of vitamin K and vitamin A on the modulation of hypervitaminosis D3 toxicity in rats by assessing serum calcium, renal function tests, cardiac enzymes, ...

Dietary phylloquinone (vitamin K1) is considered to be a major determinant of human vitamin K status. For this reason, measurements of plasma vitamin K concentrations provide a useful tool of vitamin K status in man. There is a growing interest in the role, biochemical function, and metabolism of vitamin K in vivo. A modified reversed phase-HPLC method with fluorescence detection after post-col...

VITAMIN K, AN ESSENTIAL vitamin, is a cofactor for a single known enzymatic reaction: the conversion of glutamic acid to g-carboxyglutamic acid in vitamin K-dependent proteins during their biosynthesis. Since the discovery of vitamin K and its association with blood coagulation,1 many milestones have been passed on the road to understanding the biological role of vitamin K. Important early land...