Childhood vitiligo differs from adult-onset vitiligo for several features including increased incidence of the segmental variant, higher prevalence of halo nevi, and more common family history for autoimmune diseases and atopic diathesis. The major differential diagnoses are the postinflammatory hypomelanoses for nonsegmental vitiligo and nevus depigmentosus for segmental vitiligo. From a thera...

BACKGROUND A study about the association of psoriasis and vitiligo is necessary due to possible immunologic origin of these diseases and their susceptibility loci found on chromosome 1p31. OBJECTIVE The main objective was to determine the prevalence of psoriasis among patients with vitiligo in a sample of 740 patients submitted to phototherapy and to describe their clinical features. METHOD Out...

OBJECTIVES Vitiligo is an acquired skin disease characterized by white areas on the skin. The pathogenesis of the disease is still unclear. Some findings show that oxidative stress could be an important phenomenon in the pathophysiology of vitiligo. METHODS We evaluated 16 consecutive localized vitiligo patients and 16 healthy controls of a similar age and sex distribution. We measured their ...

introduction vitiligo is an acquired pigmentary disorder of the skin and has significant harmful effects on the appearance and consequently social functions of the patients. there is no universally effective treatment for this disease, but topical steroids and levamisole have been used. this study evaluates the effects of levamisole and clobetasol with that of clobetasol in the treatment of vit...

Autoimmune disturbances and metabolic abnormalities observed in vitiligo, a disease of still unclear etiology, may provide evidence on the systemic nature of the disease. The aim of the study was to assess functional and morphological parameters of the liver and spleen, as well as the lipid profile in vitiligo-affected children, in order to ascertain whether any metabolic abnormalities or struc...

Background: Vitiligo is an acquired, idiopathic disorder characterized by milky white patches devoid of identifiable melanocytes. Despite much research, the precise etiology of vitiligo is not clear, but it has become quite clear in recent years that complex genetic, neural, immunological and autocytotoxic mechanisms play a role in its pathogenesis. In recent studies, a defective antioxidant de...

Vitiligo is a common depigmenting disorder resulting from the loss of melanocytes in the skin. The pathogenesis of the disease remains obscure, although autoimmune mechanisms are thought to be involved. Indeed, autoantibodies and autoreactive T lymphocytes that target melanocytes have been reported in some vitiligo patients. The objective of this study was to identify pigment cell antigens that...

BACKGROUND Vitiligo is an autoimmune polygenic disorder characterized by loss of pigmentation due to melanocyte destruction. The PTPN22 gene +1858 C>T single nucleotide polymorphism (rs2476601) has been shown to be associated with various autoimmune disorders. OBJECTIVE The aim of this study was to investigate whether the PTPN22 gene +1858 C>T single nucleotide polymorphism is associated with...

Vitiligo has been associated with the host's genetic profile, metabolic abnormality and immunostatus. The purpose of this study was to investigate the association of vitiligo with autoimmune diseases for 31 out of 39 subjects with vitiligo and their first-degree relatives living in a small Caucasian inbred rural community. They were compared with healthy individuals. A 2.28% prevalence of vitil...

INTRODUCTION Vitiligo is a common acquired pigmentary skin disorder. Vitamin D is responsible for skin pigmentation, increases tyrosinase activity and melanogenesis, and exhibits immunoregulatory functions. Low levels of vitamin D are associated with many autoimmune diseases, including systemic lupus, diabetes mellitus, rheumatoid arthritis, multiple sclerosis and alopecia areata. Few reports h...