Vasculogenic mimicry (VM) is a newly-defined tumor microcirculation pattern in highly aggressive malignant tumors. We recently reported tumor growth and VM formation of gallbladder cancers through the contribution of the ephrin type a receptor 2 (EphA2)/focal adhesion kinase (FAK)/Paxillin signaling pathways. In this study, we further investigated the anti-VM activity of norcantharidin (NCTD) a...

Vasculogenic mimicry (VM) is a functional microcirculation pattern in malignant tumors accompanied by endothelium-dependent vessels and mosaic vessels. VM has been identified in more than 15 solid tumor types and is associated with poor differentiation, late clinical stage and poor prognosis. Classic anti-angiogenic agents do not target endothelium-dependent vessels and are not efficacious agai...

where 7T is an element of the symmetric group Y'" (i.e., 7T is a permutation of 1,2, ... , n), 7=(tlt2 ... til), and E i.j is the elementary matrix with 1 in the i, j position and 0 elsewhere. In other words, P 1T(7) is the permutation matrix corresponding to 7T with the 1 in the ith row replaced by ti for each 1 = 1,2, . , " n. Our results are THEOREM 1. Let M(V) denote the group of all nonsin...

In this paper, an application of voltage differencing voltage transconductance amplifier (VDVTA) in the realization of voltage-mode (VM) multi-input single output (MISO) type biquad is presented. The proposed topology uses one VDVTA as an active element, two capacitors and a grounded resistor. The configuration realizes low pass (LP), high pass (HP), band pass (BP) and notch (BR) filters withou...

A new stabilized method is proposed for the 2-D Stokes flow problem. The new approach is based on the Variational Multiscale(VM) formulation. The Green’s functions for an infinite domain are adopted to compute the two-scale interaction. The method is shown to be able to stabilized low order Finite Element intepolation pairs and has a formulation similar to the one of Galerkin/Least-squares(GLS)...

Cloud computing has become more and more popular and the technology of rapid virtual machine (VM) cloning is widely used in cloud computing environment to implement the fast deployment of VMs to meet the need of bursting computational request. However, the security issue of VM cloning technology is not considered thoroughly in current approaches. This paper proposes a virtual machine cloning ap...

Virtual Machine (VM) based systems are widely used in the Internet and in corporate networks. In previous work we presented evidence that the virtualization overhead in a VM system perturbs TCP connections such that network performance deteriorates as compared to a non-VM system subject to the same user load. In this paper, we provide an explanation for these results. We show that that the unde...

Vasculogenic mimicry (VM) constitutes a novel approach for tumour blood supply and contributes to tumour metastasis and poor prognosis in patients with melanoma. Myoferlin (MYOF), a type II membrane protein involved in membrane regeneration and repair, is elevated in several malignant tumours, especially in advanced melanomas. This study aims to investigate the role and mechanism of MYOF in the...

BACKGROUND/AIMS Regulatory T (Treg) cells have been associated with neuroprotection by inhibiting microglial activation in animal models of Parkinson's disease (PD), a progressive neurodegenerative disease characterized by dopaminergic neuronal loss in the nigrostriatal system. Herein, we show that Treg cells directly protect dopaminergic neurons against 1-methyl-4-phenylpyridinium (MPP+) neuro...

Definition 1. An m-linear function f which maps the m-fold cartesian product V m of a vector space V into some other vector space W is called alternating if f(v1, . . . , vm) = 0 whenever v1, . . . , vm ∈ V and vi = vj for i 6= j. We let ∧ (V ,W ) be the vector space of mlinear alternating functions mapping V m intoW . We then define ∧m V by the property that if f ∈ ∧m(V,W ) then there exists a...