The clinical use of doxorubicin (DOX) is limited by a dose-dependent cardiotoxicity. The purpose of this study was to determine whether voluntary exercise training would confer protection against DOX cardiotoxicity in the isolated perfused rat heart. Female Sprague-Dawley rats were randomly assigned to standard holding cages (SED) or cages with running wheels (VEX) for 8 weeks. Twenty-four hour...

protein amyloid beta (a?), as the pathologic hallmark of alzheimer disease (ad), increases in the brain of diabetic patients. the aim of this study was to investigate the effect of 6 weeks of voluntary wheel running combined with allium paradoxum extract on cortex amyloid beta (a?1-42) levels in diabetic rats induced with alloxan. for this purpose, 42 male wistar rats (weight 185+1 gr, 8 weeks ...

CONTEXT Animal models can be used to investigate manual therapy mechanisms, but testing manipulation in animal models is problematic because animals cannot directly report their pain. OBJECTIVE To develop a rat model of inflammatory joint injury to test the efficacy of manual therapy in reducing nociception and restoring function. METHODS The authors induced acute inflammatory joint injury ...

OBJECTIVES The purpose of this study was to examine the effects of long-term wheel-running on tibia bone properties in T2DM Otsuka Long-Evans Tokushima Fatty (OLETF) rats. METHODS Ten five-week-old male OLETF rats were used as experimental animals and 5 Long-Evans Tokushima Otsuka (LETO) rats as controls. Half of OLETF rats performed daily voluntary wheel-running for 17 months (OLETF-EXE), wh...

OBJECTIVE(S) Peripheral stimulation of the innate immune system with lipopolysaccharide (LPS) causes prolonged depressive-like behavior in aged mice that is dependent on indoleamine 2,3 dioxygenase (IDO) activation. Regular moderate-intensity exercise training has been shown to exert neuroprotective effects that might reduce depressive-like behavior in aged mice. The purpose of this study was t...

Recent evidence postulates a role of hippocampal neurogenesis in anxiety behavior. Here we report that elevated levels of neurogenesis elicit increased anxiety in rodents. Mice performing voluntary wheel running displayed both highly elevated levels of neurogenesis and increased anxiety in three different anxiety-like paradigms: the open field, elevated O-maze, and dark-light box. Reducing neur...

The objective of the present study was to evaluate whether access to a running wheel increases voluntary physical activity in adult female and male domestic cats. Eight neutered domestic shorthair male cats (mean age 8·6 (sd 0·05) years) and eleven intact domestic shorthair female cats (mean age 3·3 (sd 0·14) years) were group housed for 22 h daily and individually housed during the feeding per...

The objective of the present study was to evaluate whether access to a running wheel increases voluntary physical activity in adult female and male domestic cats. Eight neutered domestic shorthair male cats (mean age 8·6 (SD 0·05) years) and eleven intact domestic shorthair female cats (mean age 3·3 (SD 0·14) years) were group housed for 22 h daily and individually housed during the feeding per...

Hypoxia at high altitudes is often assumed to constrain exercise capacity, but there have been few high- versus low-altitude comparisons of species native to a wide range of altitudes. Such studies are ecologically realistic, as wild-caught animals tested at their native altitude are presumably maximally acclimated (via phenotypic plasticity) or adapted (by evolutionary change) to that altitude...

We tested the hypothesis that regular aerobic exercise reverses arterial inflammation with aging. When compared with young controls (6.2 ± 0.4 mo; n = 7), old (31.3 ± 0.5 mo; n = 11) male B6D2F1 cage-restricted mice demonstrated increased arterial activation of the proinflammatory transcription factor NF-κB, as indicated by greater aortic phosphorylation of both the inhibitor of NF-κB kinase (I...