Background: Many issues might arise with surgical closure, such as postoperative pain, sternotomy scar, and arrhythmias well heart block. The purpose of this study was to identify the risk factors for complete block (CHB) among children following ventricular septal defect (VSD) closure. Methods: This retrospective work performed on 126 pediatric individuals, a history VSD closure surgically. Th...

The response of a membrane-bound Kv1.2 ion channel to an applied transmembrane potential has been studied using molecular dynamics simulations. Channel deactivation is shown to involve three intermediate states of the voltage sensor domain (VSD), and concomitant movement of helix S4 charges 10-15 Å along the bilayer normal; the latter being enabled by zipper-like sequential pairing of S4 basic ...

would be of use to know by pulsed Doppler echocardiography whether or not the origin of the murmur in question is consistent with a rheumatic process. When there has been no firm basis for the diagnosis of rheumatic fever, and pulsed Doppler echocardiography shows only a VSD, removal of the diagnosis of rheumatic fever and discontinuation of rheumatic fever prophylaxis may be considered. In cas...

Ventricular septal defects closure (VSD) depending on the anatomy and clinical setting can be performed surgically or by a hybrid and transcatheter approach. Two cases of children with VSD will be presented. Patients' defects were closed with various types of occluders made of nitinol wire mesh occluder, patent ductus arteriosus (PDA) type. The first case was a 2.5-year-old boy after cardiosurg...

BACKGROUND Ventricular septal defect (VSD) is a highly prevalent fetal congenital heart defect, which can become spontaneously closed during infancy. The current study aims to characterize fetal VSDs that were subsequently spontaneously closed in the first 2 years of life in eastern China. METHODS Between January 2011 and December 2013, 257 fetal patients diagnosed with isolated VSD by fetal ...

BACKGROUND This study is aimed at evaluating the operation techniques and clinical significance of free flap transplantation combined with skin grafting and vacuum sealing drainage (VSD) in repairing severe traumatic extensive circumferential or semi-circumferential soft-tissue defects of the lower leg. MATERIAL AND METHODS Thirty patients with severe lower leg injuries were treated by free f...

OBJECTIVE To determine by modern echocardiographic techniques the prevalence and development of cardiac abnormalities associated with ventricular septal defect (VSD). METHODS Consecutive patients referred to a tertiary centre for paediatric cardiology and attenders at an adult congenital heart disease clinic had details of clinical outcome prospectively recorded. Patients with VSD in associat...

OBJECTIVE To demonstrate the safety and efficacy of intraoperative apical ventricular septal defect (VSD) closure using a modified Rashkind double umbrella. DESIGN Descriptive study of all patients in whom intraoperative device closure of apical VSDs was attempted. SETTING A tertiary referral centre. PATIENTS Four patients with an apical VSD requiring closure, during the period January 19...

In the voltage-sensitive phosphatase Ci-VSP, conformational changes in the transmembrane voltage sensor domain (VSD) are transduced to the intracellular catalytic domain (CD) leading to its dephosphorylation activity against membrane-embedded phosphoinositides. The linker between both domains is proposed to be crucial for the VSD-CD coupling. With a combined approach of electrophysiological mea...

To identify and provide a global assessment of DNA methylation in fetal ventricular septal defect (VSD), genomic DNA extracted from fetal myocardial tissue samples with VSD (n=21) and from normal fetal myocardial tissue samples (n=15) was analyzed for gene methylation using array‑based technology. Furthermore, the KIAA0310, RAB43, SIVA1 and NDRG2 genes were randomly selected for validation anal...