نتایج جستجو برای: vulval elephantiasis
تعداد نتایج: 1882 فیلتر نتایج به سال:
1. Good LM, Francis SO, High WA. Scrotal elephantiasis secondary to hidradenitis suppurativa. J Am Acad Dermatol 2011;64:993‐4. 2. Alikhan A, Lynch PJ, Eisen DB. Hidradenitis suppurativa: A comprehensive review. J Am Acad Dermatol 2009;60:539‐61. 3. van Rappard DC, Limpens J, Mekkes JR. The off‐label treatment of severe hidradenitis suppurativa with TNF‐α inhibitors: A systematic review. J Derm...
The LIN-1 ETS transcription factor inhibits vulval cell fates during Caenorhabditis elegans development. We demonstrate that LIN-1 interacts with UBC-9, a small ubiquitin-related modifier (SUMO) conjugating enzyme. This interaction is mediated by two consensus sumoylation motifs in LIN-1. Biochemical studies showed that LIN-1 is covalently modified by SUMO-1. ubc-9 and smo-1, the gene encoding ...
The lin-2 gene is required for the induction of the Caenorhabditis elegans vulva. Vulval development is initiated by a signal from the anchor cell that is transduced by a receptor tyrosine kinase/Ras pathway. We show that lin-2 acts in the vulval precursor cell P6.p, downstream of lin-3 EGF and upstream of let-60 ras, to allow expression of the 1 degrees cell fate. lin-2 encodes a protein of re...
ARTICLE SUMMARY The LIN-1 ETS transcription factor plays a pivotal role in controlling cell fate decisions during development of the Caenorhabditis elegans vulva. Prior to activation of the RTK/Ras/ERK signaling pathway, LIN-1 functions as a SUMOylated transcriptional repressor that inhibits the primary vulval cell fate. Here we demonstrate that LIN-1 binds two proteins predicted to repress tra...
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