e know that the risk of stroke is increased in patients with trial fibrillation (AF), presumably because stagnant blood ow within the left atrium leads to thrombus formation. mportantly, 90% of thrombi, when seen by echocardiograhy in patients with nonrheumatic AF, are located in the eft atrial appendage (LAA) (1,2). Standard treatment of atients with AF is anticoagulation with warfarin. If war...

encoding proteases within any genome are easily identified, and three-dimensional structures of many proteases have been solved. Most proteolytic cleavage mechanisms and pro-tease substrate specificities have been established (the latter in some detail) 1. We are also able to block proteolytic activities with potent inhibi-tors. Transgenic approaches have been used for targeted deletions of pro...

A simple way to get cleavage o partition cellular components into dividing daughter cells, the spindle apparatus induces the formation of a cleavage furrow, but results conflict about which specific components are required for this process. By physically dissecting the spindle apparatus in grasshopper spermato-cytes, Alsop and Zhang now show on page 383 that bundled microtubules are the only st...

In this thesis the interaction of gravitational waves (gws) with electromagnetic waves (emws) in a static magnetic background field is considered. This interaction is a consequence of the general relativistic Einstein field equations. These equations dictate the excitation of electromagnetic waves when a gravitational wave interferes with a static electromagnetic background field and a similar ...