The production of the pellets in the pharmaceutical industry generally involves multi-step processing; 1 mixing, 2 wet granulation 3 spheronization 4 drying. Tangential spray rotogranulation is now being considered as an alternative since it combines number of steps into one processing unit thus reduces processing time. This work aimed to development and doe analysis of GPCG125 and optimization...

Toward further implementation of continuous tablet manufacturing, one key issue is the time needed for start-up operation because it could lead to lower product yield and reduced economic performance. The behavior not well understood; moreover, definition still unclear. This work investigates effects process parameters on in wet granulation, which a critical unit solid drug manufacturing. profi...