Metformin is a widely used insulin-sensitizing drug, though its mechanisms are not fully understood. Metformin has been shown to activate AMPK in skeletal muscle; however, its effects on the inhibitor of kappaB kinasebeta (IKKbeta) in this same tissue are unknown. The aim of this study was to (1) determine the ability of metformin to attenuate IKKbeta action, (2) determine whether changes in AM...

the effects of climate change, especially due to the increase of greenhouse gasses, have caused lots of problems that have affected different sections of society. one of the most important effects is the increase of natural disasters such as flood, drought, tropical cyclones, raising sea level, dust storm, etc. drought and flood are the most prevalent of these disasters in iran. because of the ...

introduction: the phenomenon of climate change and its consequences is a familiar topic which is associated with natural disasters such as, flooding, hurricane, drought that cause water crisis and irreparable damages. studying this phenomenon is a serious warning regarding the earth’s weather change for a long period of time. materials and methods: in order to understand and survey the impacts ...

this study was carried out to examine the effect of post hatch fasting (phf) period with and without subcutaneous injection of 0.6 ml ca-gluconate (ca-g) on productive performance and breast muscle development in broiler chicks up to day 28 of age. weight gain (wg) and feed intake (fi) were significantly reduced and fcr was increased as phf lasted for 36 h. injection of ca-g did not improve wg ...

 Environmental enrichment is one of the methods for improving fish growth performance. In the present trial, the effects of both light color and music on growth performance and survival of goldfish (Carassius auratus) (initial mean weight: 4.15±0.08 g) were investigated for 2 months. Two light color treatments (red light and white light) and three music treatments (M0: without music, M30:30 min...

Computer Assisted Transcription of Text Images (CATTI) and Key-Word Spotting (KWS) applications aim at transcribing and indexing handwritten documents respectively. They both are approached by means of Word Graphs (WG) obtained using segmentation-free handwritten text recognition technology based on N -gram Language Models and Hidden Markov Models. A large WG contains most of the relevant infor...

BACKGROUND Systemic antibiotics are routinely prescribed for severe acute malnutrition (SAM). However, there is no consensus regarding the most suitable regimen. In a therapeutic feeding centre in Khartoum, Sudan, a randomised, unblinded, superiority-controlled trial was conducted, comparing once daily intramuscular injection with ceftriaxone for 2 days with oral amoxicillin twice daily for 5 d...

Although it has been documented that daily precipitation extremes are increasing worldwide, faster increases may be expected for subdaily extremes. Here after a careful quality control procedure, we compared trends in hourly and daily precipitation extremes using a large network of stations across the United States (U.S.) within the 1950–2011 period. A greater number of significant increasing t...