AIMS In clopidogrel-treated patients undergoing coronary stenting, high on-treatment platelet reactivity was linked to a higher risk of stent thrombosis (ST). Platelet response to clopidogrel is significantly influenced by genetic factors. Recently published findings showed a highly significant impact of a common polymorphism (Q192R) within the paraoxonase-1 (PON1) gene on clopidogrel treatment...

OBJECTIVE To determine Sustained Viral Response (SVR) to Interferon (IFN) and ribavirin therapy in chronic hepatitis C patients of genotype 2 and 3. STUDY DESIGN Case series. PLACE AND DURATION OF STUDY The Garden Clinic, Lahore, from June 1997 to August 2007. METHODOLOGY All patients of both genotypes 2 and 3 receiving combination therapy were included. Standard IFN with ribavirin was st...

We present a novel method for simultaneous genotype calling and haplotype-phase inference. Our method employs the computationally efficient BEAGLE haplotype-frequency model, which can be applied to large-scale studies with millions of markers and thousands of samples. We compare genotype calls made with our method to genotype calls made with the BIRDSEED, CHIAMO, GenCall, and ILLUMINUS genotype...

Eighteen virus isolates and 22 serum samples collected between 1971 and 1997 from patients with mumps were genotyped by PCR with specific primer pairs for the A, C and D genotypes of the small hydrophobic (SH) protein gene. All serum samples were subjected to nucleotide sequence analysis of the gene, and the deduced 57-amino-acid sequences were aligned with previously published sequences from t...

INTRODUCTION Single-nucleotide polymorphisms (SNPs) associated with hepatitis C virus (HCV) clearance were identified near the IL28B gene. Coinfection by the human immunodeficiency virus (HIV) influences the course of HCV contributing to liver damage. Nevertheless, little is known about the relationship between these SNPs and HCV/HIV coinfection. Our aim was to estimate the frequencies of the a...

The role of estrogen receptor alpha (ER alpha) and estrogen receptor beta (ER beta) gene polymorphisms on semen quality is the aim of our study. One hundred fourteen men were examined in the In Vitro Fertilization Unit of Ioannina Medical School, and it was found that 85 men had normal sperm count and 29 were oligozoospermic. The genotype analysis, on DNA extracted from spermatozoa, revealed th...

Recent studies have focused on genetic polymorphism of the interleukin-6 (IL-6) gene, which has led to a better understanding of the intricate interactions between host response, microorganisms, and genetics. Genotype prevalence appears to vary by the race and ethnicity of the population studied. We used a polymerase chain reaction technique to determine the prevalence of single nucleotide poly...

Heat stress is one of the major environmental constraints for wheat production; thus, a comprehensive understanding metabolomic responses required breeding heat-tolerant varieties. In this study, metabolome genotypes Imam and Norin 61, susceptible genotype Chinese Spring were comparatively analyzed using Fourier transform infrared (FTIR) spectroscopy in combination with chemometric data mining ...

Maize (Zea mays L.) yield performance is determined by the effects of genotype and environment, × environment interaction (GEI). A complete diallel crosses 11 QPM inbred lines were evaluated under both low optimum soil nitrogen environments to identify high grain stability single-cross hybrids in six environments. The results analysis variance showed that variations among attributable genotypes...