Interleukin-1 beta converting enzyme (ICE)-like proteases, which are synthesized as inactive precursors, play a key role in the induction of apoptosis. We now demonstrate that benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK), an ICE-like protease inhibitor, inhibits apoptosis by preventing the processing of CPP32 to its active form. These results suggest that novel inhibitors ...

In this work we present a probabilistic approach to find motion patterns in manipulative tasks by looking for similarities among the relevant features along of the actions phases of a trajectories dataset. From multiples observations of human movements we can align all signals temporally to perform a learning process based on selection of relevant features by analyzing their probability distrib...

Methods Retrospective chart review of the demographic, clinical, diagnostic and genetic characteristics were studied. Results Over seven years, 12 of 1214 new cases seen in the Pediatric Rheumatology Clinic (1%) (M: F = 1:1), were diagnosed as Sarcoidosis. 11/12(91.7%) had an onset ≤4 years of age, 8/12(67%) maintained a cumulative followup of 33.7 years ( range 1-9 years). 7/12(58.3%) had rece...

background: tyrosinemia type 1 is an autosomal recessive metabolic disorder, which typically affects liver and kidneys. it is caused by a defect in fumarylacetoacetate hydrolase or fumarylacetoacetase (fah) enzyme, the final enzyme in the tyrosine degradation pathway. the disease typically manifests as early onset type in early infancy with acute hepatic crisis with hepatomegaly and bleeding te...

a 28-year-old man with neurofibromatosis type 1(nf1) presented with a tumor in the sciatic nerve and femoral nerve. the differential diagnosis of malignant peripheral nerve sheath tumor was based on clinical, radiological, and histological evidence. the tumor apparently originated in sciatic nerve at the posterior aspect of the left thigh. the lesion was resected totally without neural damage t...

Fetal sex ratios (FSRs) have important implications for managing small isolated populations. Mean male-biased FSRs ranging from 2.67:1 to 1:1 have been reported for the endangered Florida Key deer (Odocoileus virginianus clavium). Several general hypotheses have been proposed that describe the manner in which FSR may vary within a deer population over time: (1) tendency to equalize the sex rati...