BACKGROUND Tetrandrine, a bisbenzylisoquinoline alkaloid, has cancer cell cytotoxicity. The effects of combined tetrandrine and radiation, alone or combined, on human SH-SY5Y neuroblastoma cells were examined. MATERIALS AND METHODS A combination treatment, using either concomitant irradiation at the beginning or end of the tetrandrine treatment (designated as the RT-Tet and Tet-RT protocols, ...

The main inhibitory action of p27, a cyclin-dependent kinase inhibitor (CDKI), arises from its binding with the cyclin E/cyclin-dependent kinase 2 (Cdk2) complex that results in G(1)-S arrest. Degradation of p27 is mediated by phosphorylation of Thr-187 of p27, which follows ubiquitination. In this study, we generated two adenoviruses expressing wild-type p27 (ad-p27wt) and mutant p27 (ad-p27mt...

One of the most striking nonclassical features of quantum mechanics is in the correlations it predicts between spatially separated measurements. In local hidden variable theories, correlations are constrained by Bell inequalities, but quantum correlations violate these. However, experimental imperfections lead to loopholes whereby LHV correlations are no longer constrained by Bell inequalities,...

This document is the second in a series of reports on the exciting physics that would be accessible at Fermilab in the event of an upgraded proton source. Where the first report covered a broad range of topics, this report focuses specifically on three areas of study: there are brief discussions on the new measurements one could make in both the neutron and anti-proton sectors, and then a detai...

BACKGROUND The effects of nuts on major cardiovascular disease (CVD) risk factors, including dose-responses and potential heterogeneity by nut type or phytosterol content, are not well established. OBJECTIVES We examined the effects of tree nuts (walnuts, pistachios, macadamia nuts, pecans, cashews, almonds, hazelnuts, and Brazil nuts) on blood lipids [total cholesterol, low-density lipoprote...