Withanolides are a group of naturally occurring steroidal lactones present in roots and leaves of Withania somnifera (L.) Dunal. Withanolides possesses a wide range of pharmacological activities including anticancer to treat various neurodegenerative disorders such as Alzheimer’s, Parkinson’s and Huntington’s diseases. In recent years, several pharmacological studies have been conducted to util...

Withania somnifera (L.) Dunal is a valued medicinal plant with pharmaceutical applications. The present study was undertaken to analyze the salicylic acid induced leaf transcriptome of W. somnifera. A total of 45.6 million reads were generated and the de novo assembly yielded 73,523 transcript contig with average transcript contig length of 1620 bp. A total of 71,062 transcripts were annotated ...

Sleep disruption involves extensive changes in physiological function, including EEG, motor, metabolic, autonomic processes physiological homeostasis and psychological balance that are necessary for physical health. Benzodiazepines are the most widely used drugs for the sleep related problems in spite of their limitations and side effects. Objective of the study was to investigate the protectiv...

Withania somnifera has been used in traditional medicine for a variety of neural disorders. Recently, chronic neurodegenerative conditions have been shown to benefit from treatment with this extract. To evaluate the action of this extract on traumatically injured neurons, the efficacy of W. somnifera root extract as a neuroprotective agent was examined in cultured model neurons exposed to an in...

The family of Solanaceae includes about 90 genera and over 2000 speeies. Among them a great number of important plants has agronomie and phannaeeutieal uses. They contai n alkaloids and triterpenoids as main aetive eonstituents. Among the last eompounds, it is important to eonsider a group of eompounds speeifie to Salanaceae, the withanolides, present in partieular in Withania samnifera. W samn...

We report on the antimicrobial activity of a cream formulation of silver nanoparticles (AgNPs), biosynthesized using Withania somnifera extract. Aqueous extracts of leaves promoted efficient green synthesis of AgNPs compared to fruits and root extracts of W. somnifera. Biosynthesized AgNPs were characterized for their size and shape by physical-chemical techniques such as UV-visible spectroscop...