Problem statement: The role of 5-HT has been investigated in many behavioral activities. Thus, studies using raphe lesion showed that 5-HT is involved in sleep, general activity levels, habituation, aggression, pain sensitivity and morphine analgesia, avoidance behavior, self-stimulation and water consumption. Approach: The metabolic interaction between serotonin (5hydroxytrptamine) and indole-...

Xanthine oxidase is molybdenum and iron-containing flavoprotein, catalyzing the final oxidation stage of purines oxidative transformation pterins some aliphatic aromatic aldehydes. Despite importance this enzyme, distribution xanthine in traditional household animal’s milk tissues unknown. Formerly, we have found most molecules animal are inactive because a lack molybdenum. Ovine was processed ...

By A. MAzUR AND A. CARLETON T HE RESULTS of studies in our laboratory’ lend support to the hypothesis that the release of iron from ferritin stores in the liver is mediated by the enzyme xanthine oxidase acting as a dehydrogenase. In this reaction the reduced enzyme, formed as a result of oxidation of xanthine or hypoxanthine to uric acid, is reoxidized by some of the ferric iron of ferritin wh...

The superoxide radical O2.-, whether produced by the xanthine/xanthine oxidase reaction or infused as KO2, solubilized by a crown ether in dry dimethyl sulphoxide, initiated a free-radical chain oxidation of anionic 2-nitropropane. Superoxide dismutase, but not catalase, inhibited oxidation of the nitroalkane. Xanthine oxidase suffered a syncatalytic inactivation, during the co-oxidation of 2-n...

In peroxisomes isolated from pea leaves (Pisum sativum L.) the production of superoxide free radicals (O(2) (-)) by xanthine and NADH was investigated. In peroxisomal membranes, 100 micromolar NADH induced the production of O(2) (-) radicals. In the soluble fractions of peroxisomes, no generation of O(2) (-) radicals was observed by incubation with either NADH or xanthine, although xanthine oxi...