To assess the contribution to mutagenesis by human DNA repair defects, a UV-treated shuttle vector plasmili, p/.189, was passed through fibroblasts derived from Japanese \eroderma pigmentosum (XP) patients in two different DNA repair complementation groups (A and F). Patients with XP have clinical and cellular UV hypersensitivity, increased fre quency of skin cancer, and defects in DNA repair. ...

CS: Cockayne syndrome ERCC5: Excision Repair Cross-complementing Rodent Repair Deficiency Complementation Group 5 gene NER: Nucleotide excision repair UV: Ultraviolet WES: Whole exome sequencing XP: Xeroderma pigmentosum XP-G: Xeroderma pigmentosum complementation group G INTRODUCTION Xeroderma pigmentosum (XP) is an autosomal recessive genodermatosis caused by a germline loss of function in DN...

Four experiments were conducted to determine the effects of dietary supplementation of corn distillers dried grain with solubles (DDGS) diets with mannanase on performance, apparent total tract digestibility (ATTD) of energy and nutrients, blood metabolites, and carcass characteristics of grower-finisher pigs. In Exp. 1, 96 grower pigs (initial BW, 57.6 kg), 6 pigs per pen and 4 pens per treatm...

The current study was conducted to determine the possibility of replacing soybean meal (SBM) in finisher pig diet completely with hydrolyzed feather meal (FM) with blood by supplementing with appropriate amino acids (AA) based on standardized ileal digestible (SID) AA in FM. Corn– SBM, positive control (POS) diets were formulated to contain 6.6 and 5.2 g true ileal digestible (TID) Lys/kg to sa...

Few issues in swine production are as complex as floor space allowances. One method for pork producers to calculate floor space allowance (A) is to convert BW into a 2-dimensional concept yielding an expression of A = k * BW(0.667). Data on ADG, ADFI, and G:F were obtained from published peer-reviewed studies. Five data sets were created: A = grower-finisher pigs, fully slatted floors, and cons...

Sixteen castrated male pigs (averaging 21.2 +/- 4.9 kg) were used in two trials to investigate the effect of dietary amino acid content during the grower phase on growth performance and N balance. In each trial, pigs were assigned randomly to corn-soybean meal grower diets formulated to contain 5.0 or 11.0 g lysine/kg (as-fed basis). Common Finisher 1 and 2 diets were offered when pigs reached ...

Xeroderma pigmentosum (XP) is one of a number of autosomal recessive syndromes in humans characterized by a marked predisposition to cancer. Fibroblasts from these pa tients show a defect in DMA repair. The XP hétérozygotes also show elevated skin cancer incidence, but reports concerning their DNA repair capacity are conflicting. In this study, the DNA repair capacity of four XP hétérozygot...

Xeroderma pigmentosum (XP) is a rare recessive heredity disease caused by DNA repair impairment characterized by photosensitivity and neurologic symptoms in half of the cases. There are eight subtypes of XP: XP-A-XP-G and XP variant. Among eight subtypes, XP complementation group A (XP-A) display the lowest DNA repair ability and the severest cutaneous and neurologic symptoms. While its pathoge...

Extreme Programming (XP) is an agile (lightweight) software development methodology and it becomes more and more popular. XP proposes many interesting practices, but it also has some weaknesses. From the software engineering point of view the most important issues are: maintenance problems resulting from very limited documentation (XP relies on code and test cases only), and lack of wider persp...

Agile methods, such as eXtreme Programming (XP), have been criticised for being inadequate for the development of secure software. In this paper, we analyse XP from a security engineering standpoint, to assess to what extent the method can be used for development of security critical software. This is done by analysing XP in the light of two security engineering standards; the Systems Security ...