OBJECTIVE To determine the pharmacokinetic (PK) profile of a proprietary formulation of methylphenidate (MPH) in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) in a phase 1 study. Methylphenidate extended-release orally disintegrating tablets (MPH XR-ODTs) combine two technologies in a single-tablet formulation-an extended-release profile that was designed for onc...

3-Amino-l,2,4-benzotriazine-l,4-dioxide (SR 4233) is a bioreductive anticancer drug which has a high selective toxicity to hypoxic cells. We have characterized the DNA and chromosome damage in wild-type Chinese hamster ovary (CHO) cells and mutant XR-1 cells after expo sure to SR 4233 under hypoxia and compared it to the damage produced by ionizing radiation (7-rays). Using the technique of pul...

Plants respond to synthetic chemicals by eliciting a xenobiotic response (XR) that enhances the expression of detoxifying enzymes such as glutathione transferases (GSTs). In agrochemistry, the ability of safeners to induce an XR is used to increase herbicide detoxification in cereal crops. Based on the responsiveness of the model plant Arabidopsis thaliana to the rice safener fenclorim (4,6-dic...

Although static magnetic fields (SMFs) are used extensively in the occupational and medical fields, few comprehensive studies have investigated their possible genotoxic effect and the findings are controversial. With the advent of magnetic resonance imaging-guided radiation therapy, the potential effects of SMFs on ionizing radiation (IR) have become increasingly important. In this study we foc...

Living Xiphinema americanum (Xa) and X. rivesi (Xr) extracted from soil samples and stored for 1-5 days at 4 or 20 C contained aseptate fungal hyphae. The fungi directly penetrated the nematode's cuticle from spores encysted near the head. Penetration through the stoma, vulva, or anus was rare. Catenaria anguillulae (Cat), Lagenidium caudatura (Lag), Aphanomyces sp. (Aph), and Leptolegnia sp. (...

The purpose of this paper is to use the Fuzzy Set Theory, specially fuzzy rule-based systems, as a mathematical tool for modeling dynamical systems given by differential equation, whose direction field is f (IVP-f ). As fuzzy systems methodology produces input-output systems, that is, it produces m outputs from n inputs, one can see it as fr : R → R, where r is the number of rules of the rule b...

in this research, the mechanical properties of seven types of nanofilm with differing amounts of silver and silver-clay particles were studied. the elasticity of modulus, tensile strength, toughness, elongation at break, tear strength and color of nanofilms were compared with those of ordinary ldpe film. results showed that the inclusion of nano particles increased the modulus of elasticity, te...

We study the structure of linear codes over the ring Bk which is defined by Fpr [v1, v2, . . . , vk]/〈v 2 i = vi, viv j = v jvi〉 k i, j=1. In order to study the codes, we begin with studying the structure of the ring Bk via a Gray map which also induces a relation between codes over Bk and codes over Fpr . We consider Euclidean and Hermitian self-dual codes, MacWilliams relations, as well as Si...

In this paper we find a bound of the degree of rational surfaces embedded in P with a linear system of type | L − px0 − x1 − . . . − xr | We determine all the possible (families of) rational surfaces embedded in P with a linear system as above, for the particular case p = 2.

This document is subject to BCP 78 and the IETF Trust’s Legal Provisions Relating to IETF Documents (http://trustee.ietf.org/license-info) in effect on the date of publication of this document. Please review these documents carefully, as they describe your rights and restrictions with respect to this document. Code Components extracted from this document must include Simplified BSD License text...