resistant (1-3). Throughout Italy, the use of macrolides, particularly the newest ones (azithromycin and clarithromycin), has increased in the treatment of infections caused by Group A streptococci. This therapeutic approach is contrary to current guidelines, which recommend using betalactam antibiotics as firstchoice therapy and reserving macrolides only for patients allergic to betalactams. I...

Methods Exposure data (temperature, humidity and air pollution) were obtained from Environment Canada for years 2003 to 2010. Using ArcGIS, the geospatial patterns of exposures were described for regions of Ontario hosting Pan Am events. A linear trend was used to forecast expected exposures for Pan Am regions in July 2015. Health outcomes (hospitalizations, emergency department visits and outp...

This study was designed to calibrate and evaluate the subsurface drain flow component of the Root Zone Water Quality Model (RZWQM; Version 2.5) for four tillage-systems: chisel plow (CP), moldboard plow (MB), no-tillage (NT), and ridge-tillage (RT). Measured subsurface drain flow data for 1990 was used for model calibration. Main parameters calibrated were lateral saturated hydraulic conductivi...

OBJECTIVE To examine the surgical-pathological predictors of para-aortic lymph node (PAN) metastasis at radical hysterectomy, and for PAN recurrence among women who did not undergo PAN dissection at radical hysterectomy. METHODS This is a retrospective analysis of a nation-wide cohort study of surgically-treated stage IB-IIB cervical cancer (n=5,620). Multivariate models were used to identify...

A terrestrial hydrological model, developed to simulate the high-latitude water cycle, is described, along with comparisons with observed data across the pan-Arctic drainage basin. Gridded fields of plant rooting depth, soil characteristics (texture, organic content), vegetation, and daily time series of precipitation and air temperature provide the primary inputs used to derive simulated runof...

BACKGROUND In adults, body weight tends to be underestimated when based on self-reported data. Whether this discrepancy between measured and reported data exists in healthy young children is unclear. We studied whether parental reported body weight and height of 4-year-old children corresponded with measured body weight and height. In addition, we studied the determinants and the consequences o...

Binding of short antigenic peptides to major histocompatibility complex (MHC) molecules is a core step in adaptive immune response. Precise identification of MHC-restricted peptides is of great significance for understanding the mechanism of immune response and promoting the discovery of immunogenic epitopes. However, due to the extremely high MHC polymorphism and huge cost of biochemical exper...

INTRODUCTION Gastric cancer with paraaortic lymph node (PAN) metastasis have unfavorable prognosis. There are no evidence-based preoperative chemotherapy regimens available. CASE PRESENTATION A 62-year-old female was diagnosed with advanced gastric cancer and PAN metastasis. We attempted S-1/CDDP chemotherapy in six coursed and total gastrectomy as well as systematic dissection of regional ly...

Polyarteritis nodosa (PAN) is characterized by multisystem necrotizing vasculitis, primarily affecting small-to-medium-sized muscular arteries, and it is typically found in middle-aged men. PAN is rarely found in the female genital tract (including the uterus), and imaging of the uterus with PAN has not previously been reported. Reported is a case of a 78-year-old patient with uterus enlargemen...