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Linear vs. Non-linear Modelling. Case study: modelling of binding affinity of inhibitors to Trypsin.
On the set of 53 trypsin inhibitors the affinity to the covalent bound ligands is modeled using linear (MLR) and non-linear (ANN) methods. Each compound is represented by 343 chemical descriptors. The hypothesis was that linear models are not sufficiently flexible to yield the best model, because in MLR (multiple regression analysis) the number of variables (descriptors) is limited by the numbe...
Fiberoptic bronchoscopy with bronchoalveolar lavage and protected specimen brush technique has become an established method for etiologic diagnosis in severe forms of pulmonary infections during recent years. In this study, including 62 bronchoscopies in 53 patients, a standardized program, covering all important pulmonary pathogens, has been evaluated in a heterogeneous group of patients. Resu...
Twenty-two lines were crossed with 2 testers in a Line × Tester mating design 2017-18 and the resulting 44 crosses along lines, three checks i.e., BARI Hybrid Maize 9 (BHM 9), 981 Elite evaluated alpha lattice two replications, during rabi, 2018-19. Highly significant differences found among genotypes for all characters studied. Parent parents vs except ASI indicating greater diversity parental...
BACKGROUND Pleural infection is common, and has a >30% major morbidity and mortality-particularly when infection is caused by Gram-negative, Staphylococcus aureus or mixed aerobic pathogens. Standard pleural fluid culture is negative in ∼40% of cases. Culturing pleural fluid in blood culture bottles may increase microbial yield, and is cheap and easy to perform. OBJECTIVES To determine whethe...
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