Voltage-gated Kv7 (KCNQ) channels are emerging as essential regulators of smooth muscle excitability and contractility. However, their physiological role in detrusor smooth muscle (DSM) remains to be elucidated. Here, we explored the molecular expression and function of Kv7 channel subtypes in guinea pig DSM by RT-PCR, qRT-PCR, immunohistochemistry, electrophysiology, and isometric tension reco...

We investigated the mechanisms of dysmotility of the colonic circular muscle of the Crohn’s disease model rat. Contractions induced by KCl, carbachol, and Bay K 8644 were decreased in circular smooth muscles isolated from TNBS-induced colitis rat colon. However, the absolute force and Ca sensitivity of contractile proteins were not affected as assessed in α-toxin permeabilized smooth muscle. Th...

The aim of this study is to introduce a new methodology for isolation of ectopic rhythms of ambulatory electrocardiogram (ECG) holter data via appropriate statistical analyses imposing reasonable computational burden. First, the events of the ECG signal are detected and delineated using a robust wavelet-based algorithm. Then, using Binary Neyman-Pearson Radius test, an appropriate classifie...

in this paper we define weak $f$-contractions on a‎ ‎metric space into itself by extending $f$-contractions‎ ‎introduced by d‎. ‎wardowski (2012) and provide some fixed point‎ ‎results in complete metric spaces and in partially ordered complete ‎generalized metric spaces‎. ‎some relationships between weak‎ ‎$f$-contractions and $fi$-contractions are highlighted‎. ‎we also ‎give some application...

Black pepper ( Piper nigrum ) from Piperaceae and its main ingredient (piperine) reduces gastric emptying in rats. In Iranian traditional medicine, black pepper is used to relief the menorrhalgia in women. The aim of this study was to investigate the effect of black pepper fruit aqueous extract on non-pregnant rat uterus contractions and the mechanism(s) of its action. To prepare the extract, b...