Effects of dietary alpha-lipoic acid on hepatic and serum lipid concentrations and the activity and mRNA levels of lipogenic enzymes were examined in rats. Rats were fed experimental diets containing varying amounts of lipoic acid (0, 1, 2.5, 5 g/kg) for 21 d. Lipoic acid profoundly decreased serum and liver concentrations of TAG, and also lowered serum concentrations of phospholipid and NEFA, ...

Alpha lipoic acid, or just lipoic acid (LA), is a unique and potent antioxidant. It can deliver antioxidant activity in both fatand water-soluble mediums, and it is capable of having an antioxidant effect in both its oxidized (LA) and reduced (DHLA [dihydrolipoic acid]) forms (Goraca et al., 2011). This effectively allows LA to deliver its antioxidant effect to any cell or tissue type, as well ...

Ge-on-Si plasmonics holds the promise for compact and low-cost solutions in manipulation of THz radiation. We discuss here plasmonic properties doped Ge bow-tie antennas made with a low-point cost CMOS mainstream technology. These display resonances between 500 700 GHz, probed by time domain spectroscopy. show surface functionalization thin layer α-lipoic acid that red-shifts antenna about 20 G...

conclusions in our study, hydroalcoholic extract of cyperus scariosus linn. offered nephroprotection in the form of aki prevention and for the treatment of established aki. results serum creatinine was significantly increased (p < 0.05) while 24 hours urine output, urine creatinine, and serum protein were significantly decreased (p < 0.05) in rats treated with gentamicin as compared to the cont...

Alpha Lipoic Acid, or thioctic acid, is a sulfur-containing fatty acid compound that acts as a coenzyme and an antioxidant. It is called a “universal antioxidant” because of its potent ability to neutralize a wide range of free radicals. Recent studies suggest that alpha lipoic acid may improve situations in the body involving free radicals, such as heart disease and cancer, and other disorders...

25 To determine the effects of age and lipoic acid supplementation on hepatic gene 26 expression, we fed young (3 months) and old (24 months) male Fischer 344 rats a diet with 27 or without 0.2% (w/w) R-α-lipoic acid (LA) for two weeks. Total RNA isolated from liver 28 tissue was analyzed by Affymetrix microarray to examine changes in transcriptional profiles. 29 Results showed elevated pro-inf...

Antioxid Redox Signal. 2005 Jul-Aug;7(7-8):1032-9 Konrad D. Division of Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland. [email protected] Alpha-lipoic acid is a naturally occurring cofactor of mitochondrial dehydrogenase complexes and a potent antioxidant. It can interchange between a reduced form and an oxidized form, thereby displaying reducing (...