The remodeling of actin cytoskeleton osteoclasts on the bone matrix is essential for osteoclastic resorption activity. A specific regulator osteoclast cytoskeleton, integrin αvβ3, known to provide a key role in degradation mineralized matrixes. Cilengitide potent inhibitor integrins and capable affecting αvβ3 receptors, has anti-tumor anti-angiogenic apoptosis-inducing effects. However, its fun...

Thyroid hormones L-thyroxine (T4) and 3,3',5-triiodo-L-thyronine (T3) have been shown to initiate short- and long-term effects via a plasma membrane receptor site located on integrin αvβ3. Also insulin-like growth factor type I (IGF-I) activity is known to be subject to regulation by this integrin. To investigate the possible cross-talk between T4 and IGF-I in rat L6 myoblasts, we have examined...

Most of the focus in choroidal and retinal angiogenesis centers on the regulation of endothelial function by soluble factors. Less well-understood, but nevertheless significant, is the regulation of endothelial cell function by its insoluble microenvironment, the extracellular matrix (ECM). Endothelial interaction with the ECM occurs primarily through cell surface receptors belonging to the int...

BACKGROUND Implantation defect is one of these contributing factors for unexplained infertility. In the mid-luteal phase, when implantation is expected to happen, Integrins expression is remarkably increased. So, Integrins could potentially serve as markers for the frame of the window of implantation. αVβ3 integrin could have a role as a potential receptor for embryonic attachment. The aim of t...

OBJECTIVE The aetiology and early pathophysiological mechanisms of aortic aneurysm formation are still unknown and challenging to study in vivo. Positron emission tomography (PET) is a potentially valuable instrument for non-invasive in vivo pathophysiological studies. No specific tracer to identify the pathophysiological process of aneurysmal dilatation is yet available, however. The aim of th...

PURPOSE This study aimed to explore the diagnostic performance of single photon emission computed tomography / computerized tomography (SPECT/CT) using a new radiotracer 99mTc-RGD-BBN for breast malignant tumor compared with 99mTc-3P4-RGD2. METHODS 6 female patients with breast malignant tumors diagnosed by fine needle aspiration cytology biopsy (FNAB) who were scheduled to undergo surgery we...

I t has long been appreciated that angiogenesis can contribute to the induction or progression of several diseases, including retinopathies, arthritis, psoriasis, and cancer. 1,2 Because endothelial cells typically exist in a quiescent state in normal vessels, the molecular changes required for these cells to become proliferative and invasive have long been considered potential targets for the ...

Background: Integrin αvβ3 (alphavbeta3) expression has recently been identified as a prognostic biomarker predicting the tumor invasion and vascularization. This study collected all relevant researches and explored the correlation of αvβ3 expression with malignant metastasis. Methods: We searched PubMed, Web of Science, Cochrane Library, CNKI, VIP and Wanfang databases with a series of inclusio...

Mimicking the biological function of the extracellular matrix is an approach to developing cell adhesive biomaterials. The RGD peptide, derived from fibronectin (Fn), mainly binds to integrin αvβ3 and has been widely used as a cell adhesive peptide on various biomaterials. However, cell adhesion to Fn is thought to be mediated by several integrin subtypes and syndecans. In this study, we synthe...