Two strains of psychrotolerant bacteria, designated M7(T) and M5, isolated from Antarctic coastal marine environments were studied to determine their taxonomic position. The organisms comprised Gram-negative, rod-shaped, facultatively anaerobic cells that were motile by means of single polar flagella. Neither of the bacterial isolates had a requirement for Na(+). These two psychrotolerant strai...

Regulatory T cells (Tregs) participate in the control of the immune response. In the human system, an IL-10-secreting, T regulatory type 1 cell (Tr1)-like subset of Tregs can be induced by concurrent cross-linking of the TCR and CD46 on naive CD4(+) T cells. Because many viral and bacterial pathogens, including the major human pathogen Streptococcus pyogenes, bind to CD46, we asked whether this...

Differentiation inhibitory factor (nm23 protein) inhibited the induction of differentiation of mouse myeloid leukemia M1 and WEHI-3BD+ and human erythroleukemia HEL, KU812, and K562 cells. Block of differentiation may be associated with the aggressive behavior of leukemia. To examine the role of nm23 in human myeloid leukemia, we investigated the relative levels of nm23-H1, nm23-H2, and c-myc t...

Intrinsically photosensitive retinal ganglion cells (ipRGCs) mediate both image-forming vision and non-image-forming visual responses such as pupillary constriction and circadian photoentrainment. Five types of ipRGCs, named M1-M5, have been discovered in rodents. To further investigate their photoresponse properties, we made multielectrode array spike recordings from rat ipRGCs, classified the...

Canagliflozin is an oral antihyperglycemic agent used for the treatment of type 2 diabetes mellitus. It blocks the reabsorption of glucose in the proximal renal tubule by inhibiting the sodium-glucose cotransporter 2. This article describes the in vivo biotransformation and disposition of canagliflozin after a single oral dose of [(14)C]canagliflozin to intact and bile duct-cannulated (BDC) mic...

The Brucella melitensis vaccine strain M5 is widely used to prevent and control brucellosis in animals. In this study, we determined the whole-genome sequence of M5, and conducted a comprehensive comparative analysis against the whole-genome sequence of the virulent strain 16 M and other reference strains. This analysis revealed 11 regions of deletion (RDs) and 2 regions of insertion (RIs) with...

We use the recently-constructed explicit duality transformation that relates a rotating D6-D4-D2-D0 black hole solution to a rotating M5-M2-P black string to construct a non-supersymmetric black ring in Taub-NUT that has two angular momenta, as well as M2 charges and M5 dipole moments. This is the first black ring solution that has both dipole charges and rotation along the S2 of the horizon, a...

The applicability and performance of the so-called M5 model tree machine learning technique is investigated in a flood forecasting problem for the upper reach of the Huai River in China. In one of configurations this technique is compared to multilayer perceptron artificial neural network (ANN). It is shown that model trees, being analogous to piecewise linear functions, have certain advantages...

Deep BV photometry for a large field covering the outer-halo globular cluster NGC 6229 is presented. For the first time, a colour-magnitude diagram (CMD) reaching below the main sequence turnoff has been obtained for this cluster. Previous results regarding the overall morphology of the horizontal and giant branches are confirmed. In addition, nine possible extreme horizontalbranch stars have b...

The M5–brane is investigated near critical field-strength. We show that this limit on the M5–brane reduces to the noncommutative open string limit on the D4–brane. The reduction on a two–torus leads to both the noncommutative open string limit and the noncommutative Yang–Mills limit on the D3–brane. The decoupled noncommutative five–brane is identified with the strong coupling limit of the nonc...