Smaller Ca2+ transients and systolic dysfunction in heart failure (HF) can be largely explained by reduced total sarcoplasmic reticulum (SR) Ca2+ content ([Ca]SRT). However, it is unknown whether low [Ca]SRT is manifest as reduced: (1) intra-SR free [Ca2+] ([Ca2+]SR), (2) intra-SR Ca2+ buffering, or (3) SR volume (as percentage of cell volume). Here we assess these possibilities in a well-chara...

RATIONALE Intra-sarcoplasmic reticulum (SR) free [Ca] ([Ca](SR)) provides the driving force for SR Ca release and is a key regulator of SR Ca release channel gating during normal SR Ca release or arrhythmogenic spontaneous Ca release events. However, little is known about [Ca](SR) spatiotemporal dynamics. OBJECTIVE To directly measure local [Ca](SR) with subsarcomeric spatiotemporal resolutio...

The title compounds, strontium perchlorate trihydrate {di-μ-aqua-aquadi-μ-perchlorato-strontium, [Sr(ClO4)2(H2O)3] n }, strontium perchlorate tetra-hydrate {di-μ-aqua-bis-(tri-aqua-diperchloratostrontium), [Sr2(ClO4)4(H2O)8]} and strontium perchlorate nona-hydrate {hepta-aqua-diperchloratostrontium dihydrate, [Sr(ClO4)2(H2O)7]·2H2O}, were crystallized at low temperatures according to the solid-...

objective(s): hardystonite (ht) is zn-modified silicate bioceramics with promising results for bone tissue regeneration. however, ht possesses no obvious apatite formation. thus, in this study we incorporated sr and ti into ht to prepare sr-ti-hardystonite (sr-ti-ht) nanocomposite and evaluated its in vitro bioactivity with the purpose of developing a more bioactive bone substitute material. ma...

A 4-yr study of spatial and temporal variability in the geochemistry of vadose groundwaters from caves within the Edwards aquifer region of central Texas offers new insights into controls on vadose groundwater evolution, the relationship between vadose and phreatic groundwaters, and the fundamental influence of soil composition on groundwater geochemistry. Variations in Sr isotopes and trace el...

Our study of the Seti River in far western Nepal shows that the solute chemistry of the river and its tributaries is strongly controlled by geology. The Seti flows through four distinct terranes, starting with the Tethyan sedimentary series (TSS) and Greater Himalayan series (GHS). TSS/GHS waters display Sr/Sr ratios of ,0.73 and high Sr and Ca, consistent with the composition of limestone and ...

اگرچه جهش اخلاقی در رمان و نقد ادبی دو دهه‌ی اخیر از سوی شماری منتقدین، فیلسوفان نظریه‌پردازان تصدیق می شود، اما همچنان ماهیت کم‌وکیف آن نامشخص است نیاز به ارزیابی تحلیلی ویژه دارد. این رو، مقاله بر تا چهارچوب جدیدی اخلاق را که حاکی گذر پسا‌مدرنیسم پساپسا‌مدرنیسم است، نماید. بدین منظور، قهرمانان مرزها (2016) اثر دیو اگرز، نویسنده‌‌ی معاصر آمریکایی، بررسی می‌شود. دنیایی به‌تصویر کشیده می‌شود مرد...