BACKGROUND Carbonic anhydrase inhibitors (CAI) reduce proximal reabsorption, activating tubuloglomerular feedback (TGF) and reducing glomerular filtration rate (GFR). Adenosine A(1) receptors (A(1)R) mediate the TGF response and stimulate proximal reabsorption. METHODS Clearance and micropuncture studies were performed in Wistar rats to determine whether blockade of A(1)R (KW3902 0.3 mg/kg i....

BACKGROUND The development of repetitive ankle sprains and persistent symptoms after initial ankle sprain has been termed chronic ankle instability (CAI). There is no clear indication of which measures are most important in discriminating between individuals with and without CAI. METHODS Thirty subjects with unilateral CAI and controls had measures of ankle laxity and hypomobility, static and...

Five strains of Streptomyces (CAI-24, CAI-121, CAI-127, KAI-32 and KAI-90) were earlier reported by us as biological control agents against Fusarium wilt of chickpea caused by Fusarium oxysporum f. sp. ciceri (FOC). In the present study, the Streptomyces were characterized for enzymatic activities, physiological traits and further evaluated in greenhouse and field for their plant growth promoti...

Greenhouse gases Observing SATellite-2 (GOSAT-2) will be launched in fiscal year 2018. GOSAT-2 will be equipped with two sensors: the Thermal and Near-infrared Sensor for Carbon Observation (TANSO)-Fourier Transform Spectrometer 2 (FTS-2) and the TANSO-Cloud and Aerosol Imager 2 (CAI-2). CAI-2 is a push-broom imaging sensor that has forwardand backward-looking bands to observe the optical prope...

Metabolism of a new antitumor agent, CAI (NSC 609974), was investigated in human liver tissue in vitro and in plasma and urine of patients receiving CAI. Metabolites identified by HPLC following C-labeled CAI incubation with human liver microsomes and reported as percentage of total metabolites formed were M1 (0-3.4%), M2 (4. 5-33%), M3 (60-79%), and M4 (7.2-19%). Ketoconazole, an inhibitor of ...