Early growth response-1 (Egr-1), a transcription factor which often underlies the molecular basis of myocardial ischemia/reperfusion (I/R) injury, and oxidative stress, is key to myocardial I/R injury. Silent information regulator of transcription 1(SIRT1) not only interacts with and is inhibited by Egr-1, but also downregulates reactive oxygen species (ROS) via the Forkhead box O1(FOXO1)/manga...

The early growth response factor 1 (Egr-1) gene (also known as krox24, NGFI-A, TIS8 or zif268) belongs to a family of immediate early response genes. This family of proteins contains a conserved zinc finger DNA-binding domain and can bind to a GC-rich sequence in the promoter region of target genes. Egr-1 expression is rapidly and transiently activated in many different cell types during develo...

Fibroblast growth factor 23 (FGF23) is a potent regulator of phosphate (Pi) and vitamin D homeostasis. The transcription factor, early growth response 1 (egr-1), is a biomarker for FGF23-induced activation of the ERK1/2 signaling pathway. We have shown that ERK1/2 signaling blockade suppresses renal egr-1 gene expression and prevents FGF23-induced hypophosphatemia and 1,25-dihydroxyvitamin D (1...

Using in situ hybridization and immunohistochemical techniques, we examined the expression pattern of egr-1 mRNA and Egr-1 Ž . protein in several brain regions following administration of 3,4-methylenedioxymethamphetamine MDMA . Furthermore, we also Ž . Ž . studied the role of N-methyl-D-aspartate NMDA receptor, dopamine D receptor, 5-hydroxytryptamine 5-HT transporter or 5-HT 1 2A receptor in ...

The Fas ligand (FasL)/Fas pathway is crucial for homeostasis of the immune system and peripheral tolerance. Peripheral lymphocyte deletion involves FasL/Fas in at least two ways: coexpression of both Fas and its ligand on T cells, leading to activation-induced cell death, and expression of FasL by nonlymphoid cells, such as intestinal epithelial cells (IEC), that kill Fas-positive T cells. We d...

Reactive oxygen species (ROS) and oxidant stress are important mediators of cardiovascular pathologies including atherosclerosis. One source of ROS in the vasculature is free heme released from hemoglobin. Because Egr-1, the regulator of cell proliferation and apoptosis, is also induced by oxidant stress and is likewise implicated in atherosclerosis, we examined the regulation of Egr-1 by heme ...

Urea, in concentrations unique to the renal medulla, increases transcription and protein expression of several immediate–early genes (IEGs) including the zinc finger-containing transcription factor, Egr-1 . In the present study, the proximal 1.2 kb of the murine Egr-1 5 9 -flanking sequence conferred urea-responsiveness to a heterologous luciferase reporter gene when transiently transfected int...

Reactive oxygen species (ROS)-induced oxidative stress in cells is an important pathophysiological process during myocardial ischemia/reperfusion (I/R) injury, and the transcription factor Egr-1 is a master switch for various damage pathways during reperfusion injury. An in vitro model of myocardial I/R injury and H9c2 cardiomyoblast cells hypoxia/reoxygenation (H/R) was used to assess whether ...

هدف: هدف اصلی این نوشتار، تأملی بر دستاوردهای علمی استادان مدیریت آموزشی در دانشگاه‌های دولتی ایران با تأکید شناخت جهت‌گیری‌های پژوهشی آنان می‌باشد.مواد و روش‌ها: برای دستیابی به از روش پژوهش اسنادی نوع مرور نظام‌مند به‌منظور بازخوانی پژوهش‌های انجام شده توسط بهره گرفته شد. پس مراجعه صفحه شخصی حدود 170 عضو هیئت وابسته گروه‌های دارای رشته جمله گروه علوم تربیتی، پایش نمونه براساس نمونه‌گیری هدفمن...

Early growth response-1 (EGR-1) is considered a central regulator in tumor cell proliferation, migration and angiogenesis and a promising candidate for gene therapy in human astrocytomas. However, conflicting data have been reported suggesting that both tumor promoting and anti-tumor activity of EGR-1 and its regulation, expression and prognostic significance still remain enigmatic. Our study e...