OBJECTIVE The purpose of this study was to determine the utility of serum CA125 determinations in diagnosing acute salpingitis. METHODS CA125 levels were determined for 34 women with the clinical diagnosis of pelvic inflammatory disease (PID). Acute salpingitis was confirmed laparoscopically in 28 women (82.3%). RESULTS Twenty patients (71.4%) with laparoscopically confirmed acute salpingit...

AIM The aim of this study was to examine the relationship between serum and saliva levels of cancer antigen (CA) 125 and compare them among healthy women and patients with treated and untreated breast cancer. METHODS AND MATERIALS CA125 levels were assayed in serum and unstimulated whole saliva of 25 normal healthy women, 24 patients with untreated breast cancer, and 23 patients with treated ...

AIM To investigate seven CA125 criteria to monitor progressive ovarian cancer among patients with stage IC-IV disease. MATERIALS & METHODS Four criteria were used to asses CA125 increments starting from concentrations ≥35 U/ml and three criteria to asses increments starting from concentrations <35 U/ml. RESULTS A total of 231 patients were allocated to CA125 monitoring. The performances of ...

Background and aims. To determine whether reduction of CA125 levels is a predictive factor for cytoreduction to no visible residual disease (NVRD) and chemotherapeutic sensitivity in advanced epithelial ovarian carcinoma (EOC), primary carcinoma of fallopian tube and peritoneal carcinoma patients who received neoadjuvant chemotherapy followed by interval debulking surgery (NAC-IDS). Methods. Th...

The aims of this study were: to characterise and compare plasma concentrations of midkine (MDK) in normal healthy women with concentrations observed in women with ovarian cancer; and to establish and compare the performance of MDK with that of anterior gradient 2 protein (AGR2) and CA125 in the development of multi-analyte classification algorithms for ovarian cancer. Median plasma concentratio...

High-grade serous ovarian cancers (HGSCs) are deadly malignancies that relapse despite carboplatin chemotherapy. Here we show that 16 independent primary HGSC samples contain a CA125-negative population enriched for carboplatin-resistant cancer initiating cells. Transcriptome analysis reveals upregulation of homologous recombination DNA repair and anti-apoptotic signals in this population. Whil...

Detection of serum tumor markers has been developed as a non-invasive tool to assess treatment efficiency in different types of cancer. This study aims to investigate the role of preoperative serum tumor markers (CEA, CA125 and CA15-3) in the management of breast cancer, and their relationships with patients' clinicopathological parameters as well as different molecular subtypes. Altogether, 15...

Screening trials for the early detection of ovarian cancer in the general population and in patients at a high risk for this disease have so far failed to show a reduction of ovarian cancer-specific mortality. Current screening modalities include pelvic examinations, transvaginal ultrasounds, and cancer antigen 125 (CA125) serum marker levels, which are associated with a high false-positive rat...

Purpose. The study aims at investigating the most reliable CA125-related factors in terms of predicting survival outcomes in advanced-stage epithelial ovarian carcinoma (EOC) patients received neoadjuvant chemotherapy (NAC). Methods. The EOC patients treated with NAC at Peking Union Medical College Hospital by a single gynecological oncology team were enrolled for the retrospective study. The C...

Introduction: Inflammatory mediators could be laboratory markers of preeclampsia, as the induction an inflammatory process within placenta may trigger expression cancer antigen 125(CA125), C-reactive protein (CRP) and uric acid (UA). Regarding pathophysiology pre-eclampsia, there is defective trophoblastic invasion uteroplacental blood vessels that leads to placental ischemia, placenta.&#x0D; O...