Psoriasis is a immune mediated disease that affects skin characterized by hyperproliferation and inflammation of the skin. It is the most common chronic inflammatory skin disease, affecting about 2% of the general population. Skin is a major target of oxidative stress due to reactive oxygen species (ROS). This study was aimed to show that ROS play a significant role in pathogenesis of psoriasis...

The British Bangladeshi community is one of the youngest and fastest growing ethnic minority groups in the UK. Many report poor socio-economic and health profiles with the existence of substantial health inequalities, particularly in relation to type 2 diabetes. Although there is compelling evidence for the effectiveness of lifestyle interventions in the prevention of type 2 diabetes, there is ...

Overexpression of some transmembrane tyrosine kinase growth factor receptors in breast and other tumors has been found to correlate with poor prognosis. Following the cloning of the first two members of the fibroblast growth factor family of receptors (FGFRs), amplification of these receptors in breast carcinomas was found. We have examined 23 breast carcinoma cell lines to determine the extent...

Inflammation and infection downregulate the activity and expression of cytochrome P450s (P450s) and other drug metabolizing enzymes (DMEs) involved in hepatic drug clearance. Schistosoma mansoni infection was reported to cause a downregulation of hepatic P450-dependent activities in mouse liver, but little is known about the specific enzymes affected or whether phase II DMEs are also affected. ...

Acinar cell tumors of the pancreas are uncommon and they include acinar cell carcinomas, acinar cell cystadenocarcinomas and acinar cell cystadenomas (ACCs) (1-5). These tumors are composed of typical round or cylindrical cells with eosinophilic periodic acid stain (PAS)positive cytoplasmic granules. On immunohistochemical analysis, they express pancreatic enzymes, and electron microscopy demon...