Seven pure flavonolignans were isolated from an extract of milk thistle [Silybum marianum (L.) Gaertn (Asteraceae)], by semipreparative reverse-phase HPLC, and identified based on spectroscopic and LC-MS=IT-TOF data. All seven compounds were screened as potential antitumor-promoting agents by using the in vitro short-term 12-O-tetradecanoylphorbol-13-acetate (TPA)induced Epstein-Barr virus earl...

Wild mustard (Sinapis arvensis L.) and milk thistle (Silybum marianum (L.) Gaertn.) are two competitive broad-leaved weeds commonly found in cereals Europe, while several weed species have developed resistance to the main herbicides that applied on these crops. Thus, implementation of integrated management (IWM) programs is great importance. Field experiments were conducted based a split-plot d...

Silymarin, a purified extract of seeds of Silybum marianum L. and well known for its hepatoprotective abilities, has been evaluated for inherent utility as a radioprotective agent. A fraction (INM-7035) was authenticated by characterizing the percentage composition of silybin A and B (39.9% and 57.4%). Free radical scavenging activities of INM-7035 against superoxide radicals (>68%), hydroxyl r...

Silymarin, the polyphenolic fraction from Milk Thistle (Silybum marianum) and its main component silybinin, are used almost exclusively for hepatoprotection in humans. Silymarin offers good protection in various toxic models of experimental liver diseases in laboratory animals. It effects, by antioxidative, anti-inflammatory, antifibrotic, antilipid peroxidative, membrane stabilizing and liver ...

A reactive oxygen species has been implicated in a range of human pathological diseases such as atherosclerosis and certain cancers. Flavonoids are reported to exhibit various biological activities, including antioxidative and free radical scavenging activities. Several flavonoids obtained from barley leaves, soybean and some medicinal plants, Silybum marianum, Sophorae Flos, Cinnamon, Ephedrae...

Kutkins are group of pharmacologically active compounds present in Picrorhiza kurroa Royle (Scrophulariaceae). Picrorhiza kurroa is traditionally known as kutki and has intense bitter taste. In Ayurveda Picrorhiza kurroa is a reputed remedy for the treatment of liver diseases. The chemical composition of the Picrorhiza has been studied and active constituents are group of iridoid glycosides kno...