the current challenges in the management of esophageal cancer are to obtain a better understanding of underlying molecular alterations to provide new treatment options. we studied the p53 and bcl-2 protein expression in esophageal carcinomas to correlate molecular alterations with clinicopathological findings. tissue samples of 37 patients with advanced esophageal carcinoma were analyzed by imm...

Anti-apoptotic B-cell lymphoma 2 (Bcl-2) family members target several intracellular Ca(2+)-transport systems. Bcl-2, via its N-terminal Bcl-2 homology (BH) 4 domain, inhibits both inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs), while Bcl-XL, likely independently of its BH4 domain, sensitizes IP3Rs. It remains elusive whether Bcl-XL can also target and modulate Ry...

We have reported that photodynamic therapy (PDT) using the photosensitizer phthalocyanine (Pc) 4 and red light damages the antiapoptotic protein Bcl-2. Recently, using transient transfection of Bcl-2 deletion mutants, we identified the membrane anchorage domains of Bcl-2 as necessary to form the photosensitive target. However, it is not clear how Bcl-2 photodamage sensitizes cells to Pc 4-PDT-i...

این مقاله در پی آن است که با استفاده از آموزه­های اقتصاد خرد، تأثیر میزان مهریه بر رفتار ازدواجی افراد و نیز برخی مهم‌ترین تصمیمات درون­خانواده­ای را به صورت نظری بررسی تحلیل کند. نتایج حاصل تحلیل­های حاکی افزایش مهریه، قیمت ضمنی ازدواج برای مردان منجر کاهش تقاضای آنها سرریزشدن تقاضا بازارهایی می­شود جایگزینی عرضه می­شود. خالص منفعت انتظاری فرزندآوری زنان خواهد داد ایجاد انگیزه­های واگر خانواده...

Bcl-2 and its homologue Bcl-XL are expressed in a variety of tumors and their expression modulates the sensitivity of tumor cells to a wide spectrum of chemotherapeutic agents and gamma-irradiation. In the present report, we generated clones of FL5.12 lymphoid cells with similar levels of Bcl-2 and Bcl-XL using the Flag epitope to determine if these survival proteins could provide equivalent pr...