Antineoplastic drugs are a wide and heterogeneous group of substances that, as universally known, can cause highly severe toxic effects to whoever is exposed. From an occupational safety point view, surface contaminations inside preparation administration units growing issue therefore require the development implementation sensible fast monitoring methods. The unlikelihood unique all-embracing ...

BACKGROUND Cancer treatment costs are increasing; the global cost of antineoplastic medications rose to $83.7 billion in 2015. As a result, it is imperative for institutions to implement cost-saving strategies and to maximize reimbursement for costly medications such as antineoplastic drugs. OBJECTIVES Evaluate the necessity and drug costs of administering antineoplastic medications in the in...

Antineoplastic drugs (ANPDs) are a heterogeneous group of chemicals that include alkylating agents (e.g., cyclophosphamide, melphalan, chlorambucil), antimetabolites (e.g., thioguanine, 5-fluorouracil, methotrexate), antibiotics (e.g., doxorubicin), mitotic spindle inhibitors (e.g., vincristine), hormones (e.g., diethylstilbestrol, free radical generators (e.g., bleomycin) and topoisomerase inh...

Poly (ADP-ribose) polymerase 1 (PARP1), the best-studied isoform of the nuclear enzyme PARP family, plays a pivotal role in cellular biological processes, such as DNA repair, gene transcription, and so on. PARP1 has been found to be overexpressed in various carcinomas. These all indicate the clinical potential of PARP1 as a therapeutic target of human malignancies. Additionally, multiple precli...

The Salmonella reversion test was used to measure the mutagenic activities of urine concentrates from individuals preparing cancer chemotherapy agents for i.v. administration. Longitudinal studies were performed in which the total urine produced in 24-hr periods was collected, starting on a Sunday at 7 p.m. after a duty-free weekend and extending over an 8-day period. There was no detectable in...

Chemotherapy has not only proved valuable in treating many diseases but the history of discovery of some drugs makes exciting reading. The aim of this article is to outline one such story.

Introduction Australia and Canada have parallel submission processes that allow companies to submit their dossier the respective Health-Technology-Assessment (HTA) body before market authorization is issued, aiming provide timelier access drugs. The objective of this study investigate associations submissions with rollout times HTA recommendations new active substances (NASs). Methods Public da...

This paper describes the mechanisms of action of ionizing radiations combined with antineoplastic drugs. Some relevant drugs for the combined modality treatments of locally advanced lung cancer are reported. The meta-analyses including randomized trials comparing single agent (radiotherapy or chemotherapy) versus combined chemotherapy and radiotherapy in patients with unresectable non small cel...