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MOTIVATION Group-wise pattern analysis of genes, known as gene-set analysis (GSA), addresses the differential expression pattern of biologically pre-defined gene sets. GSA exhibits high statistical power and has revealed many novel biological processes associated with specific phenotypes. In most cases, however, GSA relies on the invalid assumption that the members of each gene set are sampled ...

Beyond the conviction that Major Depression can found its origin in genetics [1-3] a bio molecular mechanism could be hypothesized from what emerged from the studies on platelets fatty acid composition in human (normal and depressive subjects) which allowed classifying the depressive disorder [4] using an Artificial Neural Network (Self Organizing Map-SOM) [5], as mathematical tool, because of ...

Proline metabolism is an important pathway that has relevance in several cellular functions such as redox balance, apoptosis, and cell survival. Results from different groups have indicated that substrate channeling of proline metabolic intermediates may be a critical mechanism. One intermediate is pyrroline-5-carboxylate (P5C), which upon hydrolysis opens to glutamic semialdehyde (GSA). Recent...

The effect of 20 L-amino acids upon pancreatic glucagon secretion has been studied in conscious dogs. Each amino acid was administered intravenously over a 15 min period in a dose of 1 mmole/kg of body weight to a group of four or five dogs. Pancreatic glucagon and insulin were measured by radioimmunoassay. 17 of the 20 amino acids caused a substantial increase in plasma glucagon. Asparagine ha...

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doi: 10.1130/0091-7613(1996)024<0766:SRATRD>2.3.CO;2 1996;24;766-767 Geology Robert P. Sharp, Dwight L. Carey, John B. Reid , Jr., Pratigya J. Polissar and Michael L. Williams and Reply Sliding rocks at the Racetrack, Death Valley: What makes them move?: Comment Email alerting services cite this article to receive free e-mail alerts when new articles www.gsapubs.org/cgi/alerts click Subscribe t...

doi: 10.1130/G31117.1 2010;38;1091-1094 Geology Pearson and Feng Sheng Hu Michael A. Urban, David M. Nelson, Gonzalo Jiménez-Moreno, Jean-Jacques Châteauneuf, Ann Middle Miocene − Oligocene grasses in southwestern Europe during the Early 4 Isotopic evidence of C Email alerting services articles cite this article to receive free e-mail alerts when new www.gsapubs.org/cgi/alerts click Subscribe t...

The ecological impacts of emerging pollutants such as pharmaceuticals are not well understood. The lack of experimental approaches for the identification of pollutant effects in realistic settings (that is, low doses, complex mixtures, and variable environmental conditions) supports the widespread perception that these effects are often unpredictable. To address this, we developed a novel scree...

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