Innate lymphoid cells (ILC) are lymphocytes lacking rearranged antigen receptors such as those expressed by T and B cells. ILC are important effector and regulatory cells of the innate immune system, controlling lymphoid organogenesis, tissue inflammation, and homeostasis. The family of ILC consists of cytotoxic NK cells and the more recently described noncytotoxic group 1, 2, and 3 ILC. The cl...

Invasive lobular carcinoma (ILC) and lobular neoplasia (LN) are two distinct conditions that still pose challenges regarding to their classification, diagnosis and management. Although they share similar cellular characteristics, such as discohesive neoplastic cells and absence of e-cadherin staining, they represent completely different conditions. LN encompasses atypical lobular hyperplasia (A...

The two main histological types of infiltrating breast cancer, lobular (ILC) and the more common ductal (IDC) carcinoma are morphologically and clinically distinct. To assess the molecular alterations associated with these breast cancer subtypes, we conducted a whole-genome study of 166 archival estrogen receptor (ER)-positive tumors (89 IDC and 77 ILC) using the Affymetrix GeneChip(R) Mapping ...

We comparatively investigated the expression and clinical implications of lipid metabolism-related proteins in invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) of the breast. A total of 584 breast cancers (108 ILC and 476 IDC) were subjected to tissue microarray and immunohistochemical analysis for lipid metabolism-related proteins including hormone-sensitive lipase (HSL), p...

The idea of iterative control of batch processes has been discussed in the literature for some time. Many related concepts have been published under the names iterative control, learning control, run-to-run control, and others. This article uses the name iterative learning control (ILC). The main idea of ILC is illustrated in Fig. 1. An ILC controller provides feedforward control input to a pla...

We present the analysis on the quadrupole phases of the Internal Linear Combination map, ILC(I) and (III) derived by the WMAP team (1 and 3-year data release). This approach allows us to see the global trend of non-Gaussianity of the quadrupoles for the ILC(III) map through phase correlations with the foregrounds. Significant phase correlations is found in between the ILC(III) quadrupole and th...

In previous work, we compared the raster tracking performance of two distinct combined feedforward/feedback control architectures while using model-inverse control [1], [2]. In this paper, we extend that previous work into the application of parallel and serial iterative learning control (ILC) architectures. These ILC architectures naturally relate to the two previously studied combined feedfor...

The norm-optimal iterative learning control (ilc) algorithm for linear systems is extended to an estimation-based normoptimal ilc algorithm where the controlled variables are not directly available as measurements. A separation lemma is presented, stating that if a stationary Kalman filter is used for linear time-invariant systems then the ilc design is independent of the dynamics in the Kalman...

PURPOSE We queried whether comprehensive genomic profiling using a next-generation sequencing-based assay could identify novel and unanticipated targets of therapy for patients with relapsed invasive lobular carcinoma (ILC). EXPERIMENTAL DESIGN DNA sequencing (Illumina HiSeq 2000) was conducted for 3,320 exons of 182 cancer-related genes and 37 introns of 14 genes frequently rearranged in can...