In October 1997, the Italian and Dutch GRB teams started a collaboration on ESO optical follow-up of rapidly and accurately localized GRBs. Subsequently, starting April 1, 2000, this collaboration was extended to astronomers from other countries, who contributed their expertise for the creation of a Consortium committed to the study of GRB counterparts and host galaxies at optical and near-infr...

NY-ESO-1-specific CD4(+) T cells are of interest for immune therapy against tumors, because it has been shown that their transfer into a patient with melanoma resulted in tumor regression. Therefore, we investigated how NY-ESO-1 is processed onto MHC class II molecules for direct CD4(+) T cell recognition of melanoma cells. We could rule out proteasome and autophagy-dependent endogenous Ag proc...

The existence of overlapping CD8+ and CD4+ T-cell epitopes within certain tumor antigens provides an opportunity to test the hypothesis that relatively short peptides could be used to generate both CD8+ and CD4+ T cells against tumor. In this report, T-cell responses to a fragment of the tumor antigen NY-ESO-1 that contained an HLA-DP4-restricted helper T cell epitope as well as an HLA-A2-restr...

in recent year, the evolutionary structural optimization (eso) method, has been applied as an effective tool for structures design. the concept of eso method is to use the finite element  results in each iteration of process and removal of inefficient material based on these results. in this method there are several experimental parameters such as rejection rate and evolutionary rate that are e...

A robust two-degree-of-freedom control scheme is proposed for permanent magnet synchronous motor PMSM using extended state observer ESO . The robustness is achieved based on the ESO. Parameter perturbation and external disturbances in PMSM drive system are treated as disturbance variable, and then the motion model of PMSM is transformed into an extended state model by introducing this disturban...

The VST (VLT Survey Telescope) is a 2.6 m Alt-Az telescope to be installed at Mount Paranal in Chile, in the European Southern Observatory (ESO) site. The VST is a wide-field imaging facility planned to supply databases for the ESO Very Large Telescope (VLT) science and carry out stand-alone observations in the UV to I spectral range. This paper will focus mainly on control software aspects, de...

to evaluate the effectiveness of a single injection of bupivacaine (bpx) application for correction of eso/exodeviations this study has been performed. a retrospective review of 30 patients with eso/exodeviations less than 20 prism diopters (pd). preoperative deviations were recorded in pd, using the alternate prism cover test. postoperative angles at 1 and 3 months were measured in the same ma...

The tumor antigen NY-ESO-1 is a promising cancer vaccine target. We describe here a novel HLA-B7-restricted NY-ESO-1 epitope, encompassing amino acids 60-72 (APRGPHGGAASGL), which is naturally presented by melanoma cells. The tumor epitope bound to HLA-B7 by bulging outward from the peptide-binding cleft. This bulged epitope was not an impediment to T-cell recognition, however, because four of ...