Quinolones rapidly kill bacteria by two mechanisms, one that requires protein synthesis and one that does not. The latter, which is measured as lethal action in the presence of the protein synthesis inhibitor chloramphenicol, is enhanced by N-1 cyclopropyl and C-8 methoxy substituents, as seen with the highly lethal compound PD161144. In some compounds, such as levofloxacin, the N-1 and C-8 sub...

When does an ample line bundle on a smooth projective variety have a nonzero global section? In this paper, we show that this question is equivalent to a fundamental problem in commutative algebra regarding the equality of core and graded core for a certain associated homogeneous ideal. This builds on the project begun in [16], where it was shown that a sufficiently good algebraic understanding...

Using nonintrusive imaging techniques we have directly observed the nanoscopic details of the magnetization configuration of epitaxial and polycrystalline mesoscopic ring structures with a ,15-nm resolution. We have found head to head domain walls with different spin structures depending on ring width. Further, we can classify the geometry dependent switching processes according to the number o...

In eukaryotes, the replicative helicase is the large multisubunit CMG complex consisting of the Mcm2-7 hexameric ring, Cdc45, and the tetrameric GINS complex. The Mcm2-7 ring assembles from six different, related proteins and forms the core of this complex. In archaea, a homologous MCM hexameric ring functions as the replicative helicase at the replication fork. Archaeal MCM proteins form therm...

Magnetically induced current densities and current pathways have been calculated for six tautomers of substituted and nonsubstituted core-modified porphyrinoids with one of the pyrrole rings replaced by a thienopyrrole moiety. The calculations show that the aromatic properties of the porpyrinoid macrocycle are strongly influenced by the ethyl-formate substituent at the pyrrole ring of the thien...

The main goal of using dual core spun yarn is to take advantage all properties its different components. Dual-core yarns comprising three components are currently in vogue. They combine the pleasant wear elastic with high dimensional stability. production these a challenging process even at spinning stage, but they making demands market. Such stretchable produced modified Ring frame. In this sy...

Abstract Herein, we have studied the exciton dynamics of a novel fused ring π -conjugated molecule (YS3) in solution and film states by spectroscopic measurements. This incorporates dithienonaphthobisthiadiazole as core unit that is two-dimensionally -extended ring. As result, found long lifetime YS3 films originating from reduced radiative nonradiative transitions. partly because deactivation ...

Tissue-resident dendritic cells patrol for foreign antigens while undergoing slow mesenchymal migration. Using actomyosin-based structures called podosomes, dendritic cells probe and remodel extracellular matrix topographical cues. Podosomes comprise an actin-rich protrusive core surrounded by an adhesive ring of integrins, cytoskeletal adaptor proteins and actin network filaments. Here we reve...

A series of radial thiophene-based structures consisting of a central benzene or thiophene ring surrounded by acetylene-bridged terthienyl arms has been investigated by physical and theoretical methods. Fourier transform Raman spectroscopy of the neutral solids shows that the terthiophene arms are weakly coupled across the core (benzene plus acetylene groups) likely due to cross-conjugation or ...

D. Rees and J. Sally defined the core of an R-ideal I as the intersection of all (minimal) reductions of I. However, it is not easy to give an explicit characterization of it in terms of data attached to the ideal. Until recently, the only case in which a closed formula was known is the one of integrally closed ideals in a two-dimensional regular local ring, due to C. Huneke and I. Swanson. The...