نتایج جستجو برای: سرریز منحنی پیوند wes
تعداد نتایج: 27344 فیلتر نتایج به سال:
Immune checkpoint inhibitors, which unleash a patient's own T cells to kill tumors, are revolutionizing cancer treatment. Several independent studies suggest that higher non-synonymous mutational burden assessed by whole exome sequencing (WES) in tumors is associated with improved objective response, durable clinical benefit, and progression-free survival in immune checkpoint inhibitors treatme...
The presence of multiple primary tumors (MPT) in a single patient has been identified with an increasing frequency. A critical issue is to establish if the second tumor represents an independent primary cancer or a metastasis. Therefore, the assessment of MPT clonal origin might help understand the disease behavior and improve the management/prognosis of the patient.Herein, we report a 73-year-...
PurposeNeonatal encephalopathy, which is characterized by a decreased level of consciousness, occurs in 1-7/1,000 live-term births. In more than half of term newborns, there is no identifiable etiological factor. To identify underlying genetic defects, we applied whole-exome sequencing (WES) in term newborns with neonatal encephalopathy as a prospective cohort study.MethodsTerm newborns with ne...
The World Wide Web has had a significant impact on basic operational economical components in global information rich civilizations. This impact is forcing organizations to provide justification for security from a business case perspective and to focus on security from a web application development environment perspective. This increased focus on security was the basis of a business case discu...
در این تحقیق تعداد 54 مدل فیزیکی از سرریز های پلکانی با سه شیب مختلف º8/21(z=2.5)، º56/26(z=2) و º30 (z=1.7) ساخته و مورد آزمایش قرار گرفت. نوع تاج سرریزها از منحنی استاندارد اوجی است و پلکان‌ها با شیب‌های ثابت z=1.7، z=2 و z=2.5 تا پاشنه پایین دست سرریز ادامه دارد. جهت مطالعه اثر تعداد پله‌ها در افت انرژی، تعداد پله‌های 39، ...،2،3،5،7 عدد منظور شد. هدف، بررسی تأثیر تعداد پلکان در میزان افت...
Zhao, J. 2017. Sequence based identification of genetic variation associated with intellectual disability. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1343. 35 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0007-8. Intellectual disability (ID) is a common neurodevelopmental condition, often caused by genetic defects. De novo variation (DNV...
بخش اول مطالعه ی تحریک-نشر فلوریمتریک برهمکنش بین نئوترال رد و dna توسط تفکیک منحنی چند متغیره و تحلیل فاکتوری کاهش مرتبه بر پایه ی مدل مولکولهایی که با dna پیوند بین رشته ای می دهند نقش به سزایی در بهبود سرطان ایفا می کنند. لذا تعیین ثابت های پیوند مولکولها با dna در فهم مکانیسم عمل داروها دارای اهمیت می باشد. در این مطالعه برهمکنش مولکول نئوترال رد(nr) نوعی داروی ضد سرطان با dna درph فیزی...
BACKGROUND This study reports on the use of whole exome sequencing (WES) to diagnose children with inborn errors of metabolism and other disorders in United Arab Emirates. METHODS From January 2012 to December 2014, 85 patients (46 % females) were seen in the metabolic center at Tawam Hospital (Abu Dhabi) and WES testing was requested because definitive diagnoses were not reached by conventio...
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