background: natural killer (nk) cells play an important role in early stages of innate immune responses against viral and tumoral attacks. activation of nk cells by leishmaniasis results in secretion of cytokines such as interferon (ifn)-γ and tumor necrosis factor (tnf)-α, which enhances the phagocytosis and clear­ance of parasite. lipophosphoglycan 3 (lpg3), the leishmania homologous with grp...

Chimeric antigen receptor (CAR)-modified immune cell therapy has become an emerging treatment for cancers and infectious diseases. NK-based immunotherapy, particularly CAR-NK cell, is one of the most promising 'off-the-shelf' development without severe life-threatening toxicity. However, bottleneck developing a successful achieving sufficient numbers non-exhaustive, long-lived, cells from third...

Introduction: Extranodal Natural Killer (NK)/T-cell lymphoma (NKTCL) nasal type is a rare but well-known disease with poor prognosis. NKTCL is more prevalent in Asia and comprises about 7-10% of all non-Hodgkin lymphoma cases in this region. The characteristic clinical pattern of NKTCL is the destruction of the midline structures of the mid-face. Case Report: The present study examines a case o...

Background: Lenalidomide, a synthetic immunomodulatory drug, has a wide range of features including anti-angiogenic and anti-proliferative properties. To date, researchers have shown that lenalidomide is capable of ameliorating the immune system factors and antitumor responses. Most researchers have reported that lenalidomide enhances the immune response in certain cancer patients through sever...

Increasing knowledge of cancer immunology has led to the design therapies using immune cells directly or manipulating their activity, collectively termed immunotherapy. In field immuno-oncology, research on adaptive T development CAR-T cells. Innate such as NK can also eliminate oncogenically transformed and regulate system. Considering a live drug, numerous methods for isolation activation hav...

Abstract NK cells mediate anti-leukemic immunosurveillance in AML. We hypothesized that impaired predict poor outcomes analyzed the expression of receptors on CD56 cell subsets and their corresponding ligands CD45dim blast by flow cytometry 100 AML 17 healthy bone marrows. Risk stratification, complete remission, relapse, measurable residual disease, overall survival, relapse-free ligand expres...