UNLABELLED Bacteria and archaea face continual onslaughts of rapidly diversifying viruses and plasmids. Many prokaryotes maintain adaptive immune systems known as clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated genes (Cas). CRISPR-Cas systems are genomic sensors that serially acquire viral and plasmid DNA fragments (spacers) that are utilized to target a...

Crk-associated substrate (CAS, p130Cas) is a major tyrosine phosphorylated protein in cells transformed by v-crk and v-src oncogenes. We recently reported that reexpression of CAS in CAS-deficient mouse embryo fibroblasts transformed by oncogenic Src promoted an invasive phenotype associated with enhanced cell migration through Matrigel, organization of actin into large podosome ring and belt s...

Background—Carotid artery stenting (CAS) and carotid endarterectomy (CEA) are alternative strategies for stroke prevention in patients with atherosclerotic carotid disease. Although randomized clinical trials are the gold standard for assessing the relative benefits of different treatments, observational research is necessary for determining “real-world” effectiveness. Current recommendations l...

Early endoderm formation in zebrafish requires at least three loci that function downstream of Nodal signaling but upstream of the early endodermal marker sox17: bonnie and clyde (bon), faust (fau), and casanova (cas). cas mutants show the most severe phenotype as they do not form any gut tissue and lack all sox17 expression. Activation of the Nodal signaling pathway or overexpression of Bon or...

Les Lesions Laryngees et oesophayiennes de la maladie herpetique ant ete decrit recem­ment sur 5 cas (Annales de radiologie).  Ces lesions ont evolue vers une stenose orga­nique de l'oesophage dans 3 cas. L'aspzct radiologique de ces stenoses et lear evolution sont tres pronches des stenoses caustiques.  Un cas personnel de stenose oesophagienne de Ce meme type, 3 ans apres une episode aigue ...

Crk-associated substrate (Cas) is a tyrosine-phosphorylated docking protein that is indispensable for the regulation of the actin cytoskeletal organization and cell migration in fibroblasts. The function of Cas in neurons, however, is poorly understood. Here we report that Cas is dominantly enriched in the brain, especially the cerebellum, of postnatal mice. During cerebellar development, Cas i...

We previously showed that activation of the small GTPase Cdc42 promotes breast cell migration on a collagen matrix. Here we further define the signaling pathways that drive this response and show that Cdc42-mediated migration relies on the adaptor molecule p130(Cas). Activated Cdc42 enhanced p130(Cas) phosphorylation and its binding to Crk. Cdc42-driven migration and p130(Cas) phosphorylation w...

Résumé L’accouchement d’un fœtus macrosome est une situation relativement fréquente. Il s’agit d’un accouchement à haut risque aussi bien maternel que fœtal. Les principales complications maternelles étaient représentées par l’augmentation du taux de césarienne, d’hémorragie de la délivrance et des déchirures traumatiques cervico-vaginales. La principale complication fœtale était la dystocie de...

BACKGROUND AND PURPOSE Stenosis of the carotid artery may cause reduced hemodynamic and neural function that may be ameliorated with CAS. The goal of this study was to evaluate short- and long-term hemodynamic and clinical effects after CAS. MATERIALS AND METHODS Hemodynamic parameters were acquired by PCT within 1 week before CAS and at 1 week and 1 year (10-13 months) after CAS. In ACA terr...

BACKGROUND To describe geographic variation in population-based rates of carotid artery stenting (CAS) and carotid endarterectomy (CEA) performed in Medicare beneficiaries. METHODS AND RESULTS Medicare claims and enrollment data were used to calculate age, sex, and race-adjusted rates of CAS and CEA for Medicare beneficiaries in each of 306 hospital referral regions between 1998 and 2007. Pro...