BACKGROUND In humans, persistent organic pollutants (POPs) are stored primarily in adipose tissue. Their total body burden and their contribution to obesity-associated diseases remain unclear. OBJECTIVES We characterized POP total body burden and their redistribution in obese individuals before and after drastic weight loss and compared these values with a variety of molecular, biological, an...

The purpose of this study was to explore the innervation of neuropeptide Y (NPY) in the anterior vaginal mucosa of menopausal patients suffering from pelvic organ prolapse (POP). To do this, we analyzed the distribution and expression of NPY and its correlation with the occurrence and development of POP. Changes in NPY abundance in the anterior vaginal mucosa were assessed by immunohistochemist...

Pop-out in visual search reflects the capacity of observers to rapidly detect visual targets independent of the number of distracting objects in the background. Although it may be beneficial to most animals, pop-out behaviour has been observed only in mammals, where neural correlates are found in primary visual cortex as contextually modulated neurons that encode aspects of saliency. Here we sh...

Introduction: Growing studies explored the association of polymorphism in C0L1A1 Sp1-binding site with susceptibility to pelvic organ prolapse (POP), but the results have remained controversial and conflicting. To investigate the effect of COL1A1 Sp1-binding site polymorphism on POP, we performed a meta-analysis. Methods: We searched PubMed and HuGE for case-control studies concerning the assoc...

In C. elegans embryos, a Wnt/MAPK signaling pathway downregulates the TCF/LEF transcription factor POP-1, resulting in a lower nuclear level in signal-responsive cells compared to their sisters. Although the beta-catenin WRM-1 is required for POP-1 downregulation, a direct interaction between these two proteins does not seem to be required, as the beta-catenin-interacting domain of POP-1 is dis...

OBJECTIVES Recent research suggests that inhibition at early stages of visual processing may be age invariant. We test this proposal using a priming of pop-out (PoP) measure developed by Lamy, Antebi, Aviani, and Carmel (2008. Priming of pop-out provides reliable measures of target activation and distractor inhibition in selective attention. Vision Research, 48, 30-41. doi:10.1016/j.visres.2007...

The Parallel Ocean Program (POP) is a 71,000 line-of-code program written in Fortran and MPI. POP is a component of the Community Earth System Model (CESM), which is a heavily used global climate model. Now that Coarrays are part of the Fortran standard one question raised by POP’s developers is whether Coarrays could be used to improve POP’s performance or reduce its code volume. Although Coar...

Inferring the Internet Point of Presence (PoP) level maps is gaining interest due to its importance to many areas, e.g., for tracking and studying properties of the Internet. In this chapter we survey research towards the generation of PoP level maps. The chapter introduces different approaches to automatically classify IP addresses to PoPs and discusses their strengths and weaknesses. Special ...

Objective: There is little epidemiological data regarding pelvic organ prolapse (POP) in Japan, despite it being recognized as a disease can be treated in the outpatient or inpatient settings. Our aim was to estimate the prevalence of symptomatic POP among Japanese women. Methods: This cross-sectional study evaluated 8,407 randomly selected women (20-90 years old) who were employed at the Japan...

BACKGROUND The persistent organic pollutants (POPs) are highly lipophilic and resistant to biodegradation and found in e.g. seafood and marine mammals. Greenlandic Inuit have high intake of marine food and thus high POP burden that varies according to local conditions and dietary preference. We do for the very first time report the serum POP related non-steroidal xenohormone activity of Inuit a...