DNA methylation is an epigenetic modification that regulates gene expression by DNA methyltransferases (DNMTs). Inhibition of DNMTs is a promising approach for cancer therapy. Recently, novel classes of the quinolone-based compound, SGI-1027, and RG108-procainamide conjugates, CBC12, have been identified as potent DNMT inhibitors. In this work, we report comprehensive studies using induced-fit ...

The services of general interest (SGI) hold an important place in relation to the European model society, referring functions and objectives that are essential for implementation fundamental citizen rights accomplishment economic, social territorial cohesion goals. SGI reflect obligation public authorities provide them at certain standards terms quality, availability, accessibility affordabilit...

Stormwater Green Infrastructure (SGI) systems such as rain gardens, permeable pavement and bioswales are commonly used in municipalities to reduce urban flooding water pollution. In conjunction with these direct benefits, SGI provide additional social environmental “co-benefits”. Our goal was investigate the co-benefits of five cities United States, including Baltimore, Denver, New York City, P...

Purpose: The purpose of this study was to examine the perspectives and experiences educators who practice Soka (value-creating) pedagogy in their teaching learning environment. Methodology: participants were teaching, or had taught, a formal public private education system Canada also affiliated with Gakkai International Association Educators Group. An online survey distributed describing reque...

The development of geoeducation generates a link between people, landscapes, and their culture by recognising the geological potential around geosites conservation. Geosites have important scientific value constitute way generating learning tools for geoeducation. city Guayaquil, main port Ecuador, has valuable mining heritage, which been affected population growth its invasion protected areas,...

The SGI Origin 2000 is a cache-coherent non-uniform memory access IccNUMA) tnultionxessor desipned and manufactured bv Silicon ‘Graphics,. Inc. ?he Origin sys;m was desi&d from th> ground up as a multiprocessor capable of scaling to both small and large processor counts without any bandwidth, latency, or cost cliffs.The Origin system consists of up to 512 nodes interconnected by a scalable Cray...