During interphase, the inactive X chromosome (Xi) is largely transcriptionally silent and adopts an unusual 3D configuration known as the "Barr body." Despite the importance of X chromosome inactivation, little is known about this 3D conformation. We recently showed that in humans the Xi chromosome exhibits three structural features, two of which are not shared by other chromosomes. First, like...

To probe the molecular interactions of factor XI we have prepared two monoclonal antibodies (MoAbs; 5F7 and 3C1), each of which binds the heavy chain of reduced and alkylated factor XIa. Competitive solid phase radioimmunoassay (RIA) binding studies revealed that 5F7 and 3C1 are directed against different epitopes within factor XI. One antibody (5F7) blocked the surface-mediated proteolytic act...

We are given a training set S = {(xi, yi), 1 ≤ i ≤ m}, where each xi is an instance in some space X, e.g. a feature vector over Rd, and yi is a binary label (classification). For example, xi could be a set of features of an email message and y could be a label indicating whether it is spam or not. We assume that yi = f(xi) where f : X → {0, 1} is the correct labeling of the message, i.e., the g...

This note corrects a claim made in the above-mentioned paper about the exact representation of a conditional preference network by means of a possibilistic logic base with partially ordered symbolic weights. We provide a counter-example that shows that the possibilistic logic representation is indeed not always exact. This is the basis of a short discussion on the difficulty of obtaining an exa...

BRCA1, a breast and ovarian tumor suppressor, colocalizes with markers of the inactive X chromosome (Xi) on Xi in female somatic cells and associates with XIST RNA, as detected by chromatin immunoprecipitation. Breast and ovarian carcinoma cells lacking BRCA1 show evidence of defects in Xi chromatin structure. Reconstitution of BRCA1-deficient cells with wt BRCA1 led to the appearance of focal ...

fi(xi, xi−1, . . . , x1), for i = 1, . . . , n, where fi’s are from a fixed set Ops. – Most importantly, only xi is explicitly passed to the i-th function. The algorithm must store x1, . . . , xi−1 (or some functions thereof) in memory so it can access them when computing fi. – The idea is to arrange the values in some clever way (the data structure) in order to make computing the fi (and updat...

High levels of factor XI have been implicated as a risk factor for deep venous thrombosis and possibly cardiovascular disease; however, the relationship between elevated factor XI activity and stroke has yet to be established. We retrospectively evaluated factor XI activity, factor XI antigen, and high-sensitivity C-reactive protein (hs-CRP) values in samples from 65 patients with stroke, 13 wi...

We obtain the general solution of the functional equation ∑ I⊆{1,2,... ,n} |I|=k ( ∏ i∈I j 6∈I h(xj − xi)h(xi − xj − iβ) − ∏ i∈I j 6∈I h(xi − xj)h(xj − xi − iβ) ) = 0. This equation, introduced by Ruijsenaars, guarantees the commutativity of n operators associated with the quantum Ruijsenaars-Schneider models. 2000 AMS Subject Classification: Primary 39B32 30D05 33E05

X d =g((ξi ,Xi), i ≥ 1). Here (ξi ) and g(·) are given and the Xi are independent copies of the unknown distribution X. We survey this area, emphasizing examples where the function g(·) is essentially a “maximum” or “minimum” function. We draw attention to the theoretical question of endogeny: in the associated recursive tree process Xi, are the Xi measurable functions of the innovations proces...

Fan Cheng, Jing Wang, Junping Peng, Jian Yang, Hua Fu, Xiaobing Zhang, Ying Xue, Weijun Li, Yonglie Chu & Qi Jin Department of Microbiology, Medical College of Xi’ an Jiaotong University, Xi’ an, China; Department of Biochemistry, Xi’ an Medical College, Xi’ an, China; State Key Laboratory for Molecular Virology and Genetic Engineering, Chinese Center for Disease Control and Prevention, Beijing...