The oligosaccharide donor for protein N-glycosylation, Glc(3)Man(9)GlcNAc(2)-PP-dolichol, is synthesized via a multistep pathway that starts on the cytoplasmic face of the endoplasmic reticulum (ER) and ends in the lumen where the glycosylation reaction occurs. This necessitates transbilayer translocation or flipping of the lipid intermediate Man(5)GlcNAc(2)-PP-dolichol (M5-DLO) across the ER m...

3-n-Butylphthalide (NBP) is a cardiovascular drug currently used for the treatment of cerebral ischemia. The present study aims to investigate the metabolism, pharmacokinetics, and excretion of NBP in humans and identify the enzymes responsible for the formation of major metabolites. NBP underwent extensive metabolism after an oral administration of 200 mg NBP and 23metabolites were identified ...

We derive an explicit form of the quadratic-in-fermions Dirac action on the M5 brane for an arbitrary on-shell background of 11D supergravity with non-vanishing fluxes and in presence of a chiral 2-form on M5. This action may be used to generalize the conditions for which the non-perturbative superpotential can be generated in M/string theory. We also derive the Dirac action with bulk fluxes on...