Mature microRNAs (miRNAs), derived through cleavage of pre-miRNAs by the Dicer1 enzyme, regulate protein expression in many cell-types including cells in the pancreatic islets of Langerhans. To investigate the importance of miRNAs in mouse insulin secreting β-cells, we have generated mice with a β-cells specific disruption of the Dicer1 gene using the Cre-lox system controlled by the rat insuli...

NF-kappaB (nuclear factor kappaB) proteins are key transcription factors that regulate gene expression in response to various extracellular stimuli. The pathway leading to the activation of NF-kappaB involves a complicated network that includes a number of signalling molecules. The recent identification of a wide range of negative regulators of NF-kappaB has given another layer of complexity in...

In this paper, we use the block orthogonal matching pursuit (BOMP) algorithm to recover block sparse signals x from measurements y = Ax+v, where v is a l2 bounded noise vector (i.e., ‖v‖2 ≤ ǫ for some constant ǫ). We investigate some sufficient conditions based on the block restricted isometry property (block-RIP) for exact (when v = 0) and stable (when v 6= 0) recovery of block sparse signals ...

BACKGROUND Although on the decline, smoking-related fires remain a leading cause of fire death in the United States and United Kingdom and account for over 10% of fire-related deaths worldwide. This has prompted lawmakers to enact legislation requiring manufacturers to implement reduced ignition propensity (RIP) safety standards for cigarettes. The current research evaluates how implementation ...

Orthogonal matching pursuit (OMP) is a canonical greedy algorithm for sparse signal reconstruction. When the signal of interest is block sparse, i.e., it has nonzero coefficients occurring in clusters, the block version of OMP algorithm (i.e., Block OMP) outperforms the conventional OMP. In this paper, we demonstrate that a new notion of block restricted isometry property (Block RIP), which is ...

OBJECTIVE To compare the sensitivity and specificity of luciferase immunoprecipitation (LIPS) with radioimmunoprecipitation (RIP) for the measurement of autoantibodies to the type 1 diabetes autoantigens glutamic acid decarboxylase 65 (GAD65) and insulinoma-associated protein (IA)-2beta. RESEARCH DESIGN AND METHODS Sera from 49 type 1 diabetic patients and 100 nondiabetic control subjects fro...

Rip current are fast moving and narrow currents that are strongest near the beach. They are dangerous not only for novice but also experienced swimmers. Once caught in the current, the flow of the water pulls the person away from the beach. Many people in panic try to swim against the current and end up drowning due to exhaustion since these currents are usually faster than the speed at which o...

Control of Rotary Inverted Pendulum (RIP) is a classic control problem. It represents a broader class of underactuated systems. The dynamical equations of RIP are nonlinear coupled and complex. The nonlinear feature and the complex internal dynamics makes the design of the control challenging. This paper presents swing up and stabilization both via sliding modes. Tracking control of rotary actu...

Several best effort schemes (next-hop routing) are used to transport the data in the Internet. Some of them do not perform flexible route computations to cope up with the network dynamics. With the recent trends in programmable networks, mobile agent technology seems to support more flexible, adaptable and distributed mechanism for routing. In this paper, we propose a Mobile Agent based Routing...

Neural regulation of energy expenditure is incompletely understood. By genetically disrupting GABAergic transmission in a cell-specific fashion, and by combining this with selective pharmacogenetic activation and optogenetic mapping techniques, we have uncovered an arcuate-based circuit that selectively drives energy expenditure. Specifically, mice lacking synaptic GABA release from RIP-Cre neu...