Ipsilateral breast tumor recurrence (IBTR) is an increasingly common clinical challenge. IBTRs include True Recurrences (TR; persistent disease) and New Primaries (NP; de novo tumors), but discrimination between these is difficult. We assessed tumor infiltrating leukocytes (TIL) as biomarkers for distinguishing these types of IBTR using primary tumors and matched IBTRs from 24 breast cancer pat...

Tumor infiltrating lymphocytes (TIL) were cultured from 17 B-cell lymphoma specimens derived from patients with predominantly low-grade malignancies. Specimens included 15 lymph-node biopsies, 1 malignant pleural effusion, and PBL from 1 patient with circulating lymphoma cells. The phenotypic and proliferative characteristics of TIL cultured in interleukin-2 (IL-2) were studied, as well as cyto...

We describe the integration of MLRISC, a \generic" compiler back end, with TIL, a type-directed compiler for Standard ML. The TIL run-time system uses a form of type information to enable partially tag-free garbage collection. We show how we propagate this information through the nal phases of the compiler, even though the back end is unaware of the existence of this information. Additionally, ...

Transparent Intensional Logic (TIL) is a highly expressive logic system. Its potential applications in artificial intelligence and multiagent systems are broad. We introduce the TIL-Script language, which is a computational variant of the language of TIL constructions. TILScript can be used as an alternative to FIPA SL language, whenever communication in a natural language is in need (e. g. hum...

Ad 3. Studienævnsrapport. Rapporten viser, at Dansk har pæne tal bortset fra frafaldstallet. LKØ har ringet til de studerende for at finde forklaringen på frafaldet. Løsningen kunne være en form for adgangsbegrænsning og slut med at optage studerende efter adgangsfristen. Det er også nødvendigt med en samtale med de frafaldstruede studerende. Fakultetet vil have kommentarer til frafaldet. GA fo...

Twenty separate tumor infiltrating lymphocyte (TIL) bulk cultures and a tumor cell line were originated simultaneously from a fine needle aspiration biopsy of a metastasis in a patient with melanoma (F001) previously immunized with the HLA-A*0201-associated gp100:209-217(210 M) peptide. None of the TIL recognized gp100. However, 12 recognized autologous (F001-MEL) and allogeneic melanoma cells ...

Purpose: To explore the possible correlation between programmed death ligand 1 (PD-L1)/tumor-infiltrating lymphocytes (TIL) status and clinical factors in non-small cell lung (NSCLC). Materials and Methods: A total of 126 surgical NSCLC samples with stage I to IIIA were retrospectively collected and analyzed. Immunohistochemistry (IHC) assays were used to detect PD-L1 protein expression. PD-L1 ...

BACKGROUND The patient prognosis after complete resection for pathologic stage IIIA(N2) non-small cell lung cancer (NSCLC) remains a significant concern. The clinical relevance of the host immune response to NSCLC has yet to be established. We aimed to investigate the prognostic value of tumor-infiltrating lymphocytes (TILs) in a uniform cohort of patients with completely resected stage IIIA(N2...

Transcription is a dynamic process influenced by the cellular environment: healthy, transformed, and otherwise. Genome-wide mRNA expression profiles reflect the collective impact of pathways modulating cell function under different conditions. In this review we focus on the transcriptional pathways that control tumor infiltrating CD8+ T cell (TIL) function. Simultaneous restraint of overlapping...