Atopic dermatitis (AD) is a common pruritic inflammatory skin disease. Skin barrier dysfunction plays pivotal role in AD development. A decrease acylceramides the stratum corneum may contribute to AD. However, few highly effective therapies for exist. We have reported unique, diet-induced mouse model; Hairless mice fed special diet (HR-AD) showed and, consequently, AD-like dermatitis. The was c...

Activated protein C (APC) has potent anticoagulant and anti-inflammatory properties that are mediated in part by its interactions with its cofactor protein S and the endothelial cell protein C receptor (EPCR). The protein C/APC Gla domain is implicated in both interactions. We sought to identify how the protein C Gla domain enables specific protein-protein interactions in addition to its conser...

In this review, representative types of granulomatous lymphadenitis (GLA) are described. GLA can be classified as noninfectious GLA and infectious GLA. Noninfectious GLA includes sarcoidosis and sarcoid-like reaction. The cause of sarcoidosis remains unknown, but it has good prognosis. Sarcoid-like reaction, which is considered to be a biological defense mechanism, is observed in regional lymph...

Borage (Borago officinalis L., Boraginaceae) is an herbaceous annual (Janick et al. 1989). Current interest in this crop is for its seed which contains a high percentage of gamma-linolenic acid (GLA) (allcis 6,9,12-octadecatrienoic acid) in the oil. GLA is a precursor of the prostaglandin PGE1 in the human body (Willis 1981) which is vital in many body functions, such as antithrombotic inhibito...

introduction: analysis of smile is one of the esthetic evaluations in dentistry. in the present study, gla, lid, the long axis position and the oblique axial angle of each tooth were evaluated. materials and methods: in this cross-sectional analytical study, 80 subjects with properly-aligned teeth and healthy periodontium were selected. a digital camera was to take photos of lip areas in unifor...

OBJECTIVE To compare the efficacy and safety of a concentrated formulation of insulin glargine (Gla-300) with other basal insulin therapies in patients with type 2 diabetes mellitus (T2DM). DESIGN This was a network meta-analysis (NMA) of randomised clinical trials of basal insulin therapy in T2DM identified via a systematic literature review of Cochrane library databases, MEDLINE and MEDLINE...

A magnetic Schiff’s base chitosan-glutaraldehyde/Fe3O4 composite (CHT-GLA/ZnO/Fe3O4) was developed by incorporating zinc oxide (ZnO) nanoparticles into its structure to prepare an efficient adsorbent for the removal of remazol brilliant blue R (RBBR) dye. The CHT-GLA/ZnO/Fe3O4 characterized following methods: CHN, BET, FTIR, XRD, SEM–EDX, pHpzc, and potentiometric titrations. Box-Behnken design...

Vitamin K-dependent (VKD) proteins require modification by the VKD-gamma-glutamyl carboxylase, an enzyme that converts clusters of glus to glas in a reaction that requires vitamin K hydroquinone, for their activity. We have discovered that the carboxylase also carboxylates itself in a reaction dependent on vitamin K. When pure human recombinant carboxylase was incubated in vitro with 14CO2 and ...

To study the specific role of gamma-carboxyglutamic acid (Gla) residues in prothrombin, we have isolated a series of partially carboxylated prothrombin variants from a patient with a hereditary defect in vitamin K-dependent carboxylation (Goldsmith, G. H., Pence, R. E., Ratnoff, O. D., Adelstein, D. A., and Furie, B. (1982) J. Clin. Invest. 69, 1253-1260). The three variant prothrombins, purifi...

BACKGROUND Fabry disease (FD) is caused by a deficiency of the lysosomal enzyme alpha-galactosidase A (GLA) resulting in the accumulation of globotriaosylsphingosine (Gb3) in a variety of tissues. While GLA deficiency was always considered as the fulcrum of the disease, recent attention shifted towards studying the mechanisms through which Gb3 accumulation in vascular cells leads to endothelial...