Teniposide (VM-26) and etoposide (VP-16-213) were eval uated for their effects on methotrexate transport and metabo lism in Ehrlich ascites tumor cells in vitro. VM-26 (10 JUM)does not alter influx of methotrexate but slows efflux of the drug which leads to an increase in the steady-state level of ex changeable antifolate. VM-26 stimulation of net methotrexate transport occurs within 5 min of e...

PURPOSE Ovarian peritoneal carcinomatosis is a pathology for which effective cures are currently lacking. New research protocols seek to eradicate residual micrometastases following cytoreductive surgery by using hyperthermic intraperitoneal chemotherapy (HIPEC) or radioimmunotherapy (RIT). This study aims to first develop alpha-RIT using an anti-CD138 mAb radiolabeled with an alpha-emitter, bi...

The CC chemokine, eotaxin1 (CCL11) is an important regulator of eosinophil function. A marked accumulation of eosinophils in tissues has been correlated with the up-regulation of eotaxin1 expression in several diseases. The potential therapeutic value of neutralizing the effects of eotaxin1 in inflammatory conditions (including asthma) is under investigation. A human single-chain fragment varia...

These studies explore the effects of an epipodophyllotoxin on the membrane transport and metabolism of thymidine in Ehrlich ascites tumor cells. Uptake of 3H after exposure of cells to [3H]thymidine is characterized by a rapid initial velocity that approx imates membrane transport followed by a slower rate of uptake that parallels the accumulation of phosphorylated derivatives of thymidine, pri...

[This corrects the article on p. 213 in vol. 9, PMID: 28713264.].

[This corrects the article on p. 213 in vol. 6, PMID: 25914702.].

Background. This retrospective study reviewed 213 asymptomatic neonates with common bile duct (CBD) dilatations diagnosed via ultrasound to evaluate their incidence and outcomes. Materials and Methods. From August 2001 to July 2010, 18,230 abdominal ultrasound scans were performed as newborn screening. There were 213 (1.17%) cases of CBD dilatation. Dilatation of neonatal CBD was defined when i...

We introduce a model that captures the main properties that characterize employee stock options (ESO), in particular, the likelihood of early voluntary exercise and the obligation to exercise immediately if the employee leaves the firm, except if this happens before options are vested, in which case the options are forfeited. We derive an analytic formula for the price of the ESO and analyze it...

Gestational Toxoplasma gondii infection is considered a major risk factor for miscarriage, prematurity and low birth weight in animals. However, studies focusing on this topic in humans are scarce. The objective of this study is to determine whether anti-Toxoplasma gondii maternal serum profiles correlate prematurity and low birth weight in humans. The study examined 213 pregnant women seen at ...

The radio and gamma-ray pulsar PSR J2032+4127 was recently found to be in a decadeslong orbit with the Be star MT91 213, with the pulsar moving rapidly toward periastron. This binary shares many similar characteristics with the previously unique binary system PSR B1259−63/LS 2883. Here we describe radio, X-ray, and optical monitoring of PSR J2032+4127/MT91 213. Our extended orbital phase covera...