Getting to the inner circle ontiguity between the ER and the nuclear envelope means nuclear membrane proteins have a direct shot to their target. In fact, inner nuclear membrane (INM) proteins were thought to need only to diffuse to the nucleus, pass through the nuclear pore, and then be retained by nuclear-localized binding partners. But new results suggest a more active process. Suraj Saksena...

PURPOSE Presence of simultaneous pathological and immunohistochemical nodal metastasis (pNM and iNM, respectively) and/or other clinical factors may be reliable prognostic predictors of survival in esophageal cancer patients who have undergone multidisciplinary treatment. METHODS Univariate and multivariate analysis of the data collected from 77 patients who had undergone R0 esophagectomy was...

Getting to the inner circle ontiguity between the ER and the nuclear envelope means nuclear membrane proteins have a direct shot to their target. In fact, inner nuclear membrane (INM) proteins were thought to need only to diffuse to the nucleus, pass through the nuclear pore, and then be retained by nuclear-localized binding partners. But new results suggest a more active process. Suraj Saksena...

Centrosome- and microtubule-associated proteins have been shown to be important for maintaining the neural progenitor pool during neocortical development by regulating the mitotic spindle. It remains unclear whether these proteins may control neurogenesis by regulating other microtubule-dependent processes such as nuclear migration. Here, we identify Cep120, a centrosomal protein preferentially...

Abstract Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of and report prominent targeting envelope requires import. Immunogold electron microscopy proximity ligation assay combined with STED imaging revealed preferential association inner membrane where it directly binds LaminB1,...

Our studies on homeostatic restitution of cellular and subcellular membranes showed that vesicular intracellular transport is engaged in systematic and coordinated replacement of lipids and proteins in the membranes of the secretory, non-dividing epithelial cells (Slomiany et al., J. Physiol. Pharmacol. 2004; 55: 837-860). In this report, we present evidence on the homeostatic restitution of li...