Radiotherapy is commonly used to treat a variety of solid tumors but improvements in the therapeutic ratio are sorely needed. The aim of this study was to assess the Chk1 kinase inhibitor, MK-8776, for its ability to radiosensitize human tumor cells. Cells derived from NSCLC and HNSCC cancers were tested for radiosensitization by MK-8776. The ability of MK-8776 to abrogate the radiation-induced...

Midkine (MK) and heparin-binding growth-associated molecule/ pleiotrophin form a new family of heparin-binding growth/differentiation factors. We studied MK gene expression in human tumors. In normal human reference tissues, MK was highly expressed in the mucosa! tissue of the small intestine, moderately in the thyroid, weakly in the tissues of the lung, colon, stomach, kidney, and spleen, and ...

The aim of the present study was to determine if the human erythroid (E) and megakaryocytic (MK) lineages were closely linked to the existence of a bipotent burst-forming unit (BFU) E/MK progenitor. In methylcellulose cultures, BFU-E/MK colonies were observed at day 12 and closely resembled mature BFU-E with the exception that the erythroid component was surrounded by MK. These colonies were qu...

Given any finite alphabet A and positive integers m1, ..., mk, congruences on A*, denoted by ~(m1, ..., mk) and related to a version of the Ehrenfeucht-Fraisse game, are defined. Level k of the Straubing hierarchy of aperiodic monoids can be characterized in terms of the monoids A*/~(m1, ... mk). A natural subhierarchy of level 2 and equation systems satisfied in the corresponding varieties of ...

BERNARDO M. ÁBREGO, SILVIA FERNÁNDEZ-MERCHANT, AND BERNARDO LLANO Abstract. Given integers k ≥ 1 and n ≥ 0, there is a unique way of writing n as n = ¡nk k ¢ + ¡ nk−1 k−1 ¢ + ... + ¡ n1 1 ¢ so that 0 ≤ n1 < · · · < nk−1 < nk. Using this representation, the KruskalMacaulay function of n is defined as mk (n) = ¡ nk−1 k−1 ¢ + ¡ nk−1−1 k−2 ¢ + ... + ¡ n1−1 0 ¢ . We show that if a ≥ 0 and a < mk+1 (...

Redox potentials of a menaquinone (MK-6), isolated in earlier researches from two species of the obligately anaerobic genus, Desulfovibrio, as well as two other vitamins K(2)-menaquinones (MK-5) and (MK-9)- have been determined polarographically. The measurements have been validated by determination of redox potentials of 1,4-naphthoquinone and vitamin K(1) which agree with published potentiome...

MK-2206 is an inhibitor of Akt activation. It has been investigated as an anticancer drug in clinical trials assessing the potential of pAkt targeting therapy. The purpose of this study was to identify conditions that increase the sensitivity of cancer cells to MK-2206. We found that the treatment of cancer cells with a high concentration of salinomycin (Sal) reduced total Akt protein levels bu...

Midkine (MK), a heparin-binding growth factor, can regulate cell growth, survival and differentiation. MK is expressed at high levels in a variety of human carcinomas. Recently, the urine and serum MK concentration was analyzed in gastric cancer patient. However, the association of the cytokine mRNA expression with the categorical clinicopathological variables of the tumors and the location of ...

PURPOSE Wee1 regulates key DNA damage checkpoints, and in this study, the efficacy of the Wee1 inhibitor MK-1775 was evaluated in glioblastoma multiforme (GBM) xenograft models alone and in combination with radiation and/or temozolomide. EXPERIMENTAL DESIGN In vitro MK-1775 efficacy alone and in combination with temozolomide, and the impact on DNA damage, was analyzed by Western blotting and ...

The heparin binding molecules MK and HB-GAM are involved in the regulation of growth and differentiation of many tissues and organs. Here we analyzed the expression of MK and HB-GAM in the developing mouse incisors, which are continuously growing organs with a stem cell compartment. Overlapping but distinct expression patterns for MK and HB-GAM were observed during all stages of incisor develop...