Preparation of the motor system for movement execution involves an increase in excitability of motor pathways. In a reaction time task paradigm, a startling auditory stimulus (SAS) delivered together with the imperative signal (IS) shortens reaction time significantly. In self-generated tasks we considered that an appropriately timed SAS would have similar effects. Eight subjects performed a ba...

This paper provides a web-based system using SAS, HTML and CGI/PERL to provide rudimentary and complex Sybase DBMS performance metrics for Unix based system operations. Sybase SQL Server performance data is collected by Sybase Historical Server allowing for the collection of performance information with minimal impact on the server. The SAS System (Base SAS, Macro, STAT and SAS/Graph) is especi...

BACKGROUND Idiosyncratic drug reactions such as hepatotoxicity and blood dyscrasias represent one of the major causes of drug withdrawal from the market. According to the reactive metabolite (RM) concept, this may be due to the metabolic activation of structural alerts (SAs), functionalities in the drug molecule that are susceptible to bioactivation resulting in RMs. The relationship, however, ...

Testing for the presence of linkage disequilibrium (LD) and measuring its value is important in statistical genetics. LD deals with the correlation of genetic variation at two or more loci in the genome within a given population. PROC ALLELE in SAS/GENETICS provides a variety of pair-wise LD measures that are related to the well-known Pearson correlation r. Different statistical tests of linkag...

Centrioles are cylindrical cell organelles with a ninefold symmetric peripheral microtubule array that is essential to template cilia and flagella. They are built around a central cartwheel assembly that is organized through homo-oligomerization of the centriolar protein SAS-6, but whether SAS-6 self-assembly can dictate cartwheel and thereby centriole symmetry is unclear. Here we show that Lei...

For high-throughput monitoring of the residues of sulfonamides (SAs) in edible animal tissues, a novel hapten and monoclonal-based indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) was developed. The novel hapten was synthesized and conjugated to carrier protein as immunogen. The spleen cells of the inoculated mice expressing group-specificity against SAs were fused. The obtaine...

We developed a screening method for orphan receptor ligands, in which cell-surface proteins are expressed in Drosophila embryos from GAL4-dependent insertion lines and ligand candidates identified by the presence of ectopic staining with receptor fusion proteins. Stranded at second (Sas) binds to the receptor tyrosine phosphatase Ptp10D in embryos and in vitro. Sas and Ptp10D can interact in tr...

In the SAS DATA step, you can manipulate data by instructing SAS what to do. However, SAS understands only instructions given in its own tongue. The DATA step language (SAS DSL) is simple and powerful, its syntax is crisp and highly readable, and it is easy to learn. In this presentation, we will try to introduce the basics of speaking SAS. Just like in any language, a valid SAS phrase contain...

Subjective assessments (SAs) are assigned by users against items, such as ’elegant’ and ’gorgeous’, and are common in reviews/tags in many online-sites. However, previous studies fail to effectively use SAs for improving recommendations because few users rate the same items with the same SAs, which triggers the sparsity problem in collaborative filtering. We propose a novel algorithm that links...

In Caenorhabditis elegans, five proteins are required for centriole duplication: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4. Functional orthologues of all but SAS-5 have been found in other species. In Drosophila melanogaster and humans, Sak/Plk4, DSas-6/hSas-6, and DSas-4/CPAP-orthologues of ZYG-1, SAS-6, and SAS-4, respectively-are required for centriole duplication. Strikingly, all three fly prot...